The Effects And Mechanisms Of Gushudan Against Osteoporosis

The purpose of this paper was to study the preventive and therapeutic effects of Gushudan on osteoporosis in rats after administrated prednisolone and investigate the mechanisms initially.The results indicate that:Intramuscular inject prednisolone can increase the loss of bone mass,enhance bone absorption.Gushudan(3g/kg)can increase the body weight evidently after administrated for four weeks inrats;Gushudan(1～3g/kg)can conspicuous increase the bone mineral density and bending strength tested using dual X-ray bone density absorptiometry and 78X-2 type pellet four-use radiometer and also elevate the bone's wet weight and ash weight.Gushudan(0.3～3g/kg)can increase the contents of bone calcium; Gushudan(3g/kg)increase the contents of bone phosphorus evidently.Gushudan(3g/kg) distinguished decrease ALP contents and increase BGP contents in the serum.Gushudan(1～3g/kg)conspicuous depress the calcium contents in urine;At the same time,Gushudan (3g/kg)evidently increase cAMP and decrease cGMP in plasma.The results of microcirculation manifest that Gushudan(0.3～3g/kg)can enlarge the caliber,speed up flow rate and improve the state of microcirculation.Gushudan can significantly increase the proliferation of cultured UMR106.Therefore,Gushudan has a distinct preventive and therapeutic effect on osteoporosis rats caused by administration of prednisolone.The mechanisms maybe involve increasing bone mass,inhibiting bone resorption and increasing the proliferation of cultured UMR106.