Effect Of Myocardial Injury In The Perioperative Period Of Percutaneous Coronary Intervention After Tanshinone ⅡA Pretreatment

BackgroundCoronary heart disease (CHD) is one of important disease endangering human-being's health. With technology progress, the internal medicine treatments of CHD have developed rapidly, especially the appearance of Percutaneous Coronary Intervention (PCI), it removed stenosis of coronary artery, is one of the effectivest therapy to myocardial ischemia.But PCI has its deficient. In the influence of various interfere, PCI may make mechanical damage to the walls of blood. These may lead to a series of damage to blood vessel endothelium, such as thrombosis, constriction, intima hyperplasia, vascular smooth muscle over hyperplasia, vascular migrate and reconstruction; After PCI, it may also lead to ischemical reperfusion injury. As a result, when PCI removed stenosis of coronary artery, it may make some damage to cardiac muscle.In oder to decrease the cardiac muscle damage after PCI, West medicine usually do some Pretreatment before PCI, such as: depress blood-fat, anti platelet aggregation, anticoagulation, and so on. although that, its effects are not contented. Also, there are any report mention the effect of Traditional Chinese Medicine (TCM) pretreat before PCI.ObjectiveTo make sure the effect of Myocardia injury by uesing tanshinone II A pretreat before PCI; to find the theory in accordance with using Chinese herbal medicine Pretreat before PCI. MethodsSixty qualified patients with CAD planned to receive the PCI treatment were randomly divided and single-blindedly into the conventional group and tanshinone IIA group. Before PCI, the conventional group are given routine treatment. Based on the conventional treatment, the tanshinone IIA group was given 200ml of tanshinone IIA injection by intravenous dripping once a day, begining from 7 days before operation. The TCM Syndromes score, QTd, CK-MB, cTnI, CRP, were measured at baseline and at 8 and 24 hours after the procedure.Results1. Comparing the two groups, there was no significant difference in gene-nerally condition, and also no remarkable difference in TCM Syndrome score, QTd, CK-MB, cTnI, CRP(P<0.05).2. After PCI, tanshinone IIA group was better than conventional group in TCM syndromes score and total syndrome effect (P<0.05 or P<0.01).3. 8 and 24 hours after PCI, there was no significant difference in QTd(P>0.05).4. 8 and 24 hours after PCI, comparing the two groups, the CK-MB and cTnI of tanshinone IIA group increased more significant than conventional group(P<0.05 or P<0.01).5. 8 hours PCI, the CRP of tanshinone IIA group increased more significant than conventional (P<0.05); 24 hours after PCI, there was no signig-nificant between the two group (P>0.05).ConclusionThere was some myocardia injury during percutaneous coronary intervention perioperative period; Before PCI operation, using tanshinone IIA pretreat, can mitigate the myocardia injury of the PCI, increase the clinic effect.