| Background:Cerebrovascular disease, a disorder of cerebral function, is caused by all kinds of vascular diseases. The risk factors such as hypertension, diabetes, hyperlipidemia, and smoking play an important role in vascular injure. But still now there is no confirmed and efficient treatment. So, prevention is very important.Pulse wave velocity (PWV), which is the velocity the pulse wave travels between two arterial points, can provide parameter about the aortic elasticity and assess the state of the aortic function. It is simple, economical, convenient and noninvasive. PWV has recently been receiving increasing attention as a measurement of vascular injury.The heart injects blood into the aorta pulsatingly, which will produce pulse waves on the aortic wall and propagation to the peripheral vessels in a certain velocity. PWV is determined by the biological characters of vessel wall, the vessel geometric feather and the blood density. Because the last two factors vary slightly, PWV is determined only by the stiffness of vessel wall.In the recent years, the relationship between PWV and the structural and functional changes of the vessel has been receiving more and more attention. But most focus on hypertention, coronary atherosclerotic heart disease and the interaction between artery sclerosis and them. There are only a few articles referring the relationship between PWV and Cerebrovascular disease all the world.Objective:To investigate the association between PWV and atheroslerosis of cerebral arteries, the significance of differences between PWV in the groups with and without CVD; to investigate the influences on PWV and the identities in different sites.Methods:56 patients with acute cerebral infarction (CI) and 30 patients with acute intracerebral hemorrhage (ICH) were studied. While another 30 cases without CVD served as control group, which was age- and sex-matched. All the people were measured PWV of carotid -femoral and brachial-radial in both sides within 72h after onset. The clinical data was recorded, such as age, sex, height, weight, smoking, alcohol intake, the infarct area and location in cerebral infarction patients and the site of hemorrhage.Results:We take PWV of the right side for example.1. Comparison between patients and the control:CrPWV was (10.65±1.96) m/s and cfPWV was (11.69±2.56) m/s in patients with CI, (10. 93±1. 73) m/s and (11.15±2. 95) m/s in patients with ICH. While crPWV was (9. 03±2. 02) m/s and cfPWV was (9. 60±1. 92) m/s in control.There was significant difference between crPWV and cfPWV in patients with CI and those in control (P=0. 01 and P<0. 01). There was significant difference between crPWV and cfPWV in patients with ICH and those in control (P<0. 01 and P<0.05). And there was no significant difference between crPWV and cfPWV in patients with CI and those in patients with ICH (P>0. 05 and P>0. 05) . 2. Comparison in the CI group2. 1 Comparison between patients with different infarction area:The crPWV was (10.70±1.91) m/s, (10.84±1.53) m/s and (9.90±3. 21)m/s in patients with small-area, medium-area and large-area cerebral infarction. There was no significant difference between them (P>0. 05). the cfPWV was (11.42±2.82) m/s, (12. 02±2. 36) m/s and (11.86±2. 11) m/s in patients with small-area, medium-area and large-area cerebral infarction. There was also no significant difference between them (P>0.05) .2.2 Comparison between patients with different infarction location:The crPWV was (10. 76±1. 13) m/s, (10. 47±2. 43) m/s and (10. 22±2. 28) m/s in patients with infarction in subcortex, cortex&subcortex and brainstem or cerebellum. There was no significant difference between them (P>0. 05). The cfPWV was (10. 47±2. 42)m/s, (12. 57±2. 48)m/s and (10.42±1.53) m/s in patients with infarction in subcortex, cortex&subcortex and brainstem or cerebellum. The cfPWV in patients with infarction in cortex&subcortex was higher than that in patients with infarction in brainstem or cerebellum. There was no significant difference between the other group (P>0. 05) .3. Comparison among patients with different hemorrhage location:CrPWV was (10. 50±1. 58)m/s and cfPWV was (11. 04±1. 77)m/s in patients with ICH in basal nuclei; crPWV was (11.86±1.91) m/s and cfPWV was (12.63±2.04) m/s in patients with ICH in thalamus; crPWV was (11.04±1.77) m/s and cfPWV was (10.47±2.59) m/s in patients with ICH in the other location. There was no significant difference among the three groups (P>0.05) .4. Comparison between patients with and without smocking:CrPWV was (10. 56±1. 92)m/s and cfPWV was(12.16±3. 32)m/s in patients without smocking; crPWV was (10.99±1. 79) m/s and cfPWV was (10.90±1.77) m/s in patients smocking. There was significant difference about crPWV between patients with and without smocking(P<0. 01). There was no significant difference about cfPWV between patients with and without smocking (P>0. 05) .5. Comparison among patients with different level of alcohol intake:CrPWV was (10. 61±1. 97) m/s, (10. 25±1. 79) m/s and (11.16±1.63) m/s in patient with different level of alcohol intake; cfPWV was (11.99±3.04) m/s, (10.85±1.95) m/s and (11.16±2.02) m/s in patients with different level of alcohol intake. There was no significant difference about crPWV and cfPWV among patients with different level of alcohol intake (P>0. 05) .6. Comparison about PWV in different site:CrPWV was inversely correlated with cfPWV of the right side in patient with CVD (r=0. 252, P<0. 05); there was significant correlation between crPWV and cfPWV of the left side, too (r=0. 279, P<0. 05). There was significant correlation between crPWV of both sides in patients with CVD (r=0. 329, P<0. 05). There was also significant correlation between cfPWV of both sides in patients with CVD (r=0. 865,P<0.01).Conclusion:1. PWV in patients with CI was significantly higher than cases without CI; the cfPWV in patients with infarction in cortex&subcortex was higher than that in patients with infarction in brainstem or cerebellum. There was no significant difference among patients with different infarction area.2. PWV in patients with ICH was significantly higher than cases without ICH; there was no significant difference among patients with different hemorrhage location.3. Patients with CVD have a lower cfPWV if they smock. But there was no significant difference among patients with different level of alcohol intake. 4. Both crPWV and cfPWV on one side was inversely correlated with that on the other side. On the both sides crPWV was correlated with cfPWV. |
