1. Hypertensive Cerebral Hemorrhage, Characteristic Protein Markers Of Cerebral Infarction 2. Low-level Triglycerides Increase The Risk Of All-cause Mortality In Patients With Cerebral Hemorrhage

Background and AimsStroke was the leading cause of death in China with high rate of disability and death,resulting in significant health burdens.Under high blood pressure conditions,the mechanism of cerebral vascular lesions causing different types of stroke was still unclear,although many recent researches had indicated the pathological changes and treatment.This study was aimed to identify different expression proteins in order to find the signaling pathways,novel biomarkers associated with hypertensive stroke by plasma proteomics.MethodsWe investigated healthy controls(n=15),hypertensive patients(n=15),hypertensive cerebral infarction patients(HCI,n=15)and hypertensive intracerebral hemorrhage(HICH,n=15)prospectively,and collected the base information and blood samples.The TMT-LC-MS/MS-based proteomics approach was used to quantify the different proteins across plasma samples,and the results were analyzed by bioinformatics to screen the signal pathways and specific proteins associated with HCI or HICH.ResultsThere were 191 proteins and 712 peptides quantified by high-throughput TMT labeling method.Compared with healthy controls,there were 35 differentially expressed proteins in HCI group(21 proteins were up-regulated,and 14 proteins were down-regulated),43 differentially expressed proteins in HICH group(30 proteins were up-regulated,and 14 proteins were down-regulated).Compared with hypertension group,there were 26 differentially expressed proteins in HCI group(12 proteins were up-regulated,and 14 proteins were down-regulated),31 differentially expressed proteins in HICH group(18 proteins were up-regulated,and 13 proteins were down-regulated).GO and KEGG analysis showed that the functions and pathways in the HICH group were closely related to inflammation and complement binding,while the functions and pathways in the HCI group were associated with the immune response.ConclusionThe expressed proteins in the HICH group were different from those in HCI,which provided new clues for the early-warning,prevention and treatment of the HCI and the HICH.ObjectiveTo explore the relationship between triglyceride and all-cause mortality of patients with intracerebral hemorrhage.MethodsWe investigated 467 patients with CT or MRI confirmed diagnosis of intracerebral hemorrhage from 2000 to 2001,and prospectively followed up for a median of 4.5 years.TG≤1.7 mmol/L group,n=280 and TG>1.7 mmol/L,n=187.The basic information were studied in all groups,the primary endpoint was all-causedeath.ResultsThe all-cause mortality was 23.6%.TG≤1.7 mmol/L group(30%,84/280)had higher mortality than that in TG>1.7 mmol/L group(13.9%,26/110),P<0.001.The univariate Cox regression analysis indicated that TG≤1.7 mmol/L had higher risk of all-cause mortality(HR=2.341,95%CI 1.508～3.635,P=0.001).With adjusted age,gender and other relevant factors,the low levels of TG(TG≤1.7 mmol/L)were independently related to all-cause mortality of intracerebral hemorrhage(HR=1.984,95%CI 1.258～3.13,P=0.003).ConclusionLow levels of TG had increased the risk of all-cause mortality in patients with intracerebral hemorrhage.