The Characteristics And Significance Of Arterial Elasticity And Cerebral Blood Flow In Prehypertensive Persons

Objective1. To explore the relationship between blood pressure and arterial elasticity in prehypertensive persons.2. To explore the characteristics of middle cerebral blood flow in prehypertensive persons.3. To explore the characteristics of middle cerebral arterial elasticity in prehypertensive persons.MethodsThis study was carried out at Xiangya Hospital of Central South University, China, from October2012to March2013, using cross-sectional case control study. According to blood pressure,48patients with prehypertension (prehypertension group),43patients with mild hypertension (mild hypertension group), and43subjects with normal blood pressure (normal blood pressure group) were enrolled in this study. The information collected was consisted of demographic characteristics, systolic blood pressure(SBP), diastolic blood pressure(DBP), pulse pressure(PP), mean arterial pressure(MBP), blood biochemical metabolism indexes, brachia-ankle pulse wave velocity(baPWV), ankle-brachial index(ABI), heart-ankle pulse wave velocity(haPWV),the report of transcranial doppler(TCD) and so on.Results1. BaPWV and haPWV levels in prehypertension group were higher than those in the normal blood pressure group (P<0.05), while there was no significant difference in ABI between the both groups(P>0.05). BaPWV and haPWV levels in prehypertension group were lower than those in the mild hypertension group (P<0.05).2.Multiple stepwise linear regression analysis showed that the multiple linear regression equations in prehypertension group as follows: baPWV=162.831+12.754MAP, haPWV=110.347+5.096MAP+2.567SBP.3. The systolic peak velocity(Vs) of both left middle cerebral artery (LMCA) and right middle cerebral artery (RMCA) in prehypertension group were lower than those in the normal blood pressure group (P<0.05), while the enddiastolic velocity(Vd) of LMCA and RMCA and the mean peak velocity(Vm) were similar (P<0.05). Vs, Vd, and Vm of LMCA and RMCA were no significant difference between the prehypertension group and mild hypertension group(P>0.05).4. The pulsatility index(PI)of LMCA and RMCA in prehypertension group were higher than those in the normal blood pressure group (P<0.05), and lower than those in the mild hypertension group (P<0.05). Multiple stepwise linear regression analysis showed that the multiple linear regression equations in prehypertension group as follows:PI=0.126+0.006SBP.Conclusions1. The arterial elasticity in prehypertensive persons is decreased compared with that in normal blood pressure persons, but it is better than that in mild hypertensive persons.2. The blood flow velocity of both middle cerebral arteries in prehypertensive persons is reduced compared with that in normal blood pressure persons, but it is similar to that in mild hypertensive persons.3. The middle cerebral arterial elasticity in prehypertensive persons is decreased compared with that in normal blood pressure persons, while better than that in mild hypertensive persons.