Fabrication And Characterization Of PLA-chitosan-gelatin Hybrid Porous Film

Polylactide(PDLLA and PLLA) is a kind of artificial biodegradable polymer. Gelatin is the denaturalization product of collagen and chitosan is an alkaline polysaccharide. These polymers have good biocompatibility and wide applications in the field of biomedicine. In order to expand their fields of applications, PLA-Gel-Cs hybrid porous films were fabricated through crosslinking by EDC in the NHS and MES solutions. Porous structure was formed by the way of thermally induced phase separation (TIPS). Chemical structures of the membranes were characterized via IR, DSC and XRD, the morphology via SEM,mechanical properties and properties of hydrophilicity in buffer solution were also performed. The results show that the membranes have porous structure and good hydrophilicity. Besides, the mechanical properties could be adjusted in a range through modulation of the component, supporting a positive prospect of wide application in the field of tissue engineering.