The Application Of Color Kinesis On The Diagnosis Kawasaki Disease

Objective To explore the segmental wall motion abnormality detected in children with Kawasaki disease by color kinesis dynamic display technology (CK), in order to guide clinical treatment. Methods In this study, there were forty participants at ages between two months to eight years old. And all subjects were divided into two groups: the first group, the control group including 20 normal infants in the same age group; the second group, the case group, including August 20 confirmed cases with Kawasaki disease hospitalized from August 2006 to October 2007 in the pediatrics department of our hospital (in accordance with diagnostic criteria revised by the Kawasaki disease research society of Japan in 1984), whose endocardium displacement for these patients were analyzed by using CK and 2DE. The segmental left ventricular dysfunction for all the subjects were tested by CK and 2DE at the acute phase and sub-acute phase, respectively. The diameter, the echo of the vessel wall and flow velocity of coronary artery, as well as the blood flow of four cardiac valves were emphatically recorded with pulsed-wave tissue Doppler imaging. Tei index of the left ventricle was calculated in all the subjects. At the same time, it was observed whether there were cardiac echo and pericardial effusion. All the objects were followed.Results In 20 patients with Kawasaki disease, there were 17 cases with 29 segmental wall motion abnormalities detected by CK in acute phase, and eighteen cases with 30 segmental wall motion abnormalities detected in sub-acute phase. The accuracy rate was 85% and 90% at the acute phase and sub-acute phase, respectively. In 20 cases, there were 10 cases detected with normal diameter of CA, and 10 cases with CAD by 2DE in acute phase; 4 cases found with normal diameter of CA and 16 cases with CAD in sub-acute phase. The detectable rate of CA abnormality were 50% and 80% by two dimensional echocardiogram at the acute phase and sub-acute phase, respectively. There was no significant difference in EF and FS compared with the normal group in acute phase. Fifteen case were found higher Tei index than the normal group, while it was not detected significant difference in CK and sensibility in acute phase.Conclusion The CK could detect the left ventricular segmental wall motion abnormalities in patients with KD at the acute phase, and provide some valuable indexes for evaluating the severity of the disease and prognosis of patients.