Effects Of Erzhipill On Immunological Indexes Of Aging Rats Induced By D-Galactose

With the coming of 21^stcentury,the international community has shown general attention and deeply regards towards the aging of population Beginning with the theory of traditional Chinese medicine and experimental study,the research explores the pathogenesis of aging,aiming at seeking the effective method which can delay aging.Erzhi Pill is the typical prescription for invigorating yin of the liver and kidney, which is used as the object of research.The experimental study on Erzhi Pill was researched deeply on the action and mechanism of delaying aging on sub-acute rat induced by D-galactose.Objective:To Discuss the essence of aging and research the function and mechanism of Erzhi Pill in aspect of delaying aging.Methods:Discuss the essence of aging based on the theories of traditional Chinese medicine and modern datum.Sub-acute rat of senility made by D-galactose as experimental model,Liuwei Dihuang Pill as comparative Chinese medicine and vitamin-E as comparative western medicine,this subject carries out pharmacological research of Erzhi Pill which is classified the groups of lower,midst and high dosages in order to observe the general condition of rats.Through detecting the splenic coefficient of rats,the proportion of CD4\CD8 T-lymphocyte subset and interleukin-2,the subject verifies the immunoregulatory function of delaying aging of Erzhi Pill's each dosage towards sub-acute rats of senility and approaches the part mechanism of action.Results:(1)Erzhi Pill has the functions of significantly increasing the splenic weight of rats.(2)The lower and high dosages of Erzhi Pill have better functions of increasing the proportion of CD4\CD8 T-lymphocyte subset with the increased proportion of CD4 and the decreased proportion of CD8.(3)Erzhi Pill has the functions of significantly increasing the interleukin-2 level of rats.Conclusions:Aging of human beings is always based on yin deficiency of the liver and kidney,so its treatment is invigorating yin of the liver and kidney firstly.Erzhi Pill is the typical prescription for invigorating yin of the liver and kidney calmly,which has a mild immunoregulatory function of delaying aging with reliable effect.Erzhi Pill have better functions of increasing the proportion of CD4\CD8 T-lymphocyte subset with the increased proportion of CD4 and the decreased proportion of CD8,and increasing the interleukin-2 level,thus improving the low immunity and rectifying the immunologic derangement of the sub-acute rats induced by D-galactose,which provides scientific experimental basis for the clinical application of Erzhi Pill on preventing the syndrome characterized by low immunity or immunologic derangement.