| Object: In recent years ,disease incidence of UC is upgrading in China,this arise high attention of many from medicine vocation. Kuijiean enema was used many years in Xinjiang Uighur hospital,which has conspicuous clinical effect. But this dosage form is inconvenience and restricted in application,so we change it into OCTDS in order to raise its therapeutics effect and lessen the patient's painful. Methods: 1)First of all,we progressed acute noxious experiment for oral use,which provided reference evidence for pharmacodynamics and galenic pharmacy. In this base on,a rat model of UC was induced by TNBS/ethanol in order to evaluate the effects of KJA. The microscopically and microscopically examination of the colon was detected. The immune organic relative weights were menstruated to imply the change of immune functions in rats. The activity of SOD and MPO were detected. 2)During the study of form selecting,forming and coating artwork, pH depended type colon target preparations of KJA and pH depended-time lagged type ones were acquired.AHPLC method was established in vitro dissolution determination for preparations. And the releasing site and time of the drugs from the colon-specific coated capsule in dogs were screened by X scintigraphy. Results: 1)The maximum tolerated doseof mouse is 833 times than that of man. The high doge group of KJA has appositive therapeutic effect to UC. 2)The molding techniques of pH depended type colon target preparations of KJA and pH depended-time lagged type ones were researched. The former is more simply and operability.At last,the results of authentication show that KJA colon-specific coated capsule had the colon targeting characteristics in vitro and vivo. Conclusion: This research identified Turkish galls medicinal have a small noxious and obviously therapeutic effect by oral. Exploitation of this medicine not only changed traditional administration mode for UC and elevated the level of Chinese ethical medicine's research.
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