Balloon Kyphoplasty In The Treatment Of Vertebral Compression Fractures: A Systematic Review

Objective To evaluate the efficacy and safety of balloon kyphoplasty (BK) in the management of vertebral compression fractures (VCFs). Methods This study is based on a systematic review of the literature (until October 2006) and meta-analysis of clinical studies assessing the efficacy and safety of BK in the treatment of VCFs. Meta regression analyses were carried out where required. A total of 26 studies met the inclusion criteria. Results The clinical series indicate significant improvements in pain intensity, vertebral height, sagittal alignment, functional capacity, and quality of life. Compared with conventional medical management, BK afforded significant improvement in intensity and mobility. Likewise,a significant reduction was observed in vertebral collapse, kyphotic deformity, the development of new vertebral fractures, and hospital stay. Compared with vertebroplasty,the technique reduced the loss of height and the degree of kyphotic deformity. Conclusion The available evidence suggests that BK can be effective and safe in application to VCFs. However,existing studies evince substantial methodological limitations and relatively short follow-up periods.Better clinical research is required.