| Background Systemic lupus erythematosus(SLE) is one of connective tissue diseases, and its features are generating many autoantibodies and further formation immune complexes which attack multi-system organs.The rate of kidney involvement is highest, which is 75%or so clinically,80%-90%in renal biopsy and nearly 100%in autopsy.In fact,cardiac involvement is in the higher rate(about 70%).But because the majority cardiac involvement in patient with SLE(about 50%) is a silent type;we always easily overlooked clinically.As early as 1981 some scholars described the damage of the heart, and subsequently various detection methods have been raised to improve the detection rate of cardiac,damage.Then adopted the multi-center and prospective study showed that SLE mortality caused by the heart damage was high,which was second only to infection and renal failure.After this,some scholars all over the world have proposed the different aspects of the clinical description and summary of cardiac involvement. But up to date,a large sample of lupus clinical study of heart damage is lack at home and abroad.Objective To explore the clinical features of cardiac damage in SLE,and analyze the relationships between cardiac abnomalities and some laboratory findings and clinical manifestions.Methods Clinical data for 795 SLE patients were obtained by questionnaire.The analysis was performed using EPI INFO 6.0 and SPSS13.0 programs.Results①In total,there are 303 cases of heart damage,accotmting for 38.1 percent in 795 cases,which include 15 male and 288 female cases,the male and female of the ratio of 1:19.2,average age 36.7±12.2 years,disease course-average 63.6±47.6 months and an average delayed diagnosis of 23.5 months.②Heart damage in SLE: abnormal electrocardiogram is very common,which includes ST-T anomaly 212.cases (70.0%),abnormal Q-wave six cases(2.0%) and 54 cases of arrhythmia(17.8%).ST-T ischemic changes in ECG are most frequent among the cardiac manifestations. Abnormal heart shapes include pericardial effusion in 42 cases(13.9%),myocardial damage in 12 case s(4.0%),pulmonary hypertension 9 cases(2.8%) and 24 cases of valvular heart disease(7.9%).But only 24 patients(7.9%) had clinical symptoms of heart damage.③Most patients with cardiac lesions are asymptomatic.No significant difference was identified with respect to sex(t=0.173,P=0.579) and disease-course(z =2.226,P=0.207) between the two study groups.But SLE patients with cardiac involvement have higher SLEDAI scores(z2=6.886,P=0.023) than SLE patients without cardiac involvement.④There is relatively close relationship between anticardiolipin antibody(ACA) and valve damage(χ~2=2.721,P=0.013).Conclusion①The SLE patients with cardiac impairment often have no typical symptoms.②Cardiac involvement in SLE is not associated with the disease-course and sex, but has a significant correlation with disease activity which shows SLEDAI score higher and the greater the possibility of cardiac damage.③The relations between SLE anticardiolipin antibody and heart damage are not significant,but has a positive correlation with the valve damage.④Ultrasonic cardiogram(UCG),electrocardiogram (ECG),ACA test and SLEDAI scores are well in increasing the diagnosis and active prevention and cure.
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