| As the common indexes, ALT, AST and PLT play an important role in the aspect of dignosis of diseases, direction and judgement of treatment. Most ALT is in liver cells. AST is mostly in myocardial, then in liver. Therefore, when liver is injuried, the level of ALT and AST in serum is increased with the increase of the permeability of hepatoceluar membrane. So the levels of ALT and AST in serum can suggest the injuryment of liver. Platelet has the function of hemostatic and coagulation, and can promote the regeneration and repair of vascular endothelial cells. In addition, platelet also can keep the integrity of vascular wall through filling the space caused by the abscission of vascular endothelial cells. As a result, decrease of platelet can cause the dysfuction of hemostatic and coagulation and the increase of vascular brittleness. So in clinical, the severity of hemorrhage has the association with the degree of the decrease of platelet. Platelet count is an important index in clinical. Given the improtance of serum level of ALT, AST and PLT in clinical, we must grasp their normal reference values. However, many researches suggested that there was inflammation changes and fibrosis in chronic hepatitisis B and C patients whose ALT level was persistly normal[27-32]. This finding tells us the upper limit of normal maybe higher for normal. And a large sample investigation showed that the serum level of ALT in healther is lower than the normal reference values[36].Objective: Re-evalutaion of the normal serum level of ALT, AST and PLT. Method: Investigating 3815 people in the epidemiology study of chronic disease in Jilin Province between Sep. and Oct. in 2007. We use the automatic blood analyzer 2100 produced in Aron Alpha Company in Japan to detect the platelet count and the automatic biochemistery analyzer 7600-010 produced in Hitachi Company in Japan to detect the serum levels of ALT and AST. We do statistics with SPSS12.0 for windows software. Frequencies and One-Sample Kolmogorov-Smirnov testing test the normal distribution; Nonparametric Tests test the difference between age goups, male and female, glucose groups, cholestrol groups and triglyceride groups. Percent 95 decides the nomal reference values.Result: 1. ALT level: In the five groups, there is significant difference between male and female, and the serum level in female is higher than that in male. In the group 1, there is significant difference between different age groups. In the group 2 and group 3, there is no difference between different age groups. 95% CI are 6.4U/L~73.1U/L, 6.4U/L ~71.525U/L and 6.4 U/L ~44.9U/L in group1, group2, group3, respectively. There is significant difference between different glucose groups and triglycide groups, and no difference between different cholesterol groups.2. AST level: In the five groups, there is significant difference between male and female, and the serum level in female is higher than that in male. In the group 1, there is significant difference between different age groups. In the group 2 and group 3, there is no difference between different age groups. 95% CI are 11.3U/L~49U/L, 10.9U/L ~47U/L and 10.7U/L ~37.6U/L in group1, group2, group3, respectively. There is significant difference between different glucose groups and triglycide groups, and no difference between different cholesterol groups.3. PLT level: In the three groups, there is significant difference between male and female, and the serum level in male is higher than that in female. There is significant difference between different age groups. 95% CI are 138~362×10~9/ L and 139~359×10~9/ L in group1 and group3, respectively. Conclusion: The serum levels of ALT, AST and PLT are all significantly different between male and femal, so we should difine their normal value based on the gender. The serum levels of ALT and AST is lower than the reference value. There is significant difference between different genders and age groups for PLT. The serum level of PLT is higher than the reference value. |
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