A Study On The Role Of Human Saliva On Murine Oral Candidiasis

Objective: To investigate the role of human saliva in the normal mice and xerostomia mice against oral candidiasis.Methods: By using oral inoculation we established a model of oral candidiasis on the normal mouse and xerostomia mouse. At specific intervals these mice received orally 0.1ml sterile distilled water or human saliva into the oral cavity. Three days later v iable C. albicans cells in the oral cavity of the mice were counted with plating dilution method and a subjective score for the extent of white patches on the tongue surface was determined.Results:â‘ In the normal mice, the viable counts were significantly lower in the disposal groups than in the control groups 1,2,3; Scores for white patches on the tongue were also significantly lower in the disposal groups than in the control groups 1,2,3(p<0.05);â‘¡In the xerostomia mice, the viable counts were significantly lower in the disposal groups than in the control groups. Scores for white patches on the tongue were also significantly lower in the disposal groups than in the control groups(p<0.05);â‘¢the viable counts were significantly lower in the normal groups than in the xerostomia groups. Scores for white patches on the tongue were also significantly lower in the normal groups than in the xerostomia groups (p<0.05). Conclusion: The administration of human saliva may inhibit the colonization of the oral cavity by C. albicans in mice and the subsequent onset of oral candidiasis.