The Expression Of IL-6 And IL-10 In The Intervertebral Disc And Its Correlation With Clinical Findings

Objective The expression contents of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokinesIL-10 in the intervertebral disc and its significance and correlation with clinical findings. Methods Specimens of herniated lumbar disc from 30 cases of disc herniation in single level and other 10 Specimens from corpse not dead from spinal disease. The clinical symptoms in all cases were evaluated by JOA index preparation,and make sure the patient's history, that all done by one doctor. The contents of IL-6and IL-10 in the intervertebral disc were detected by enzyme-linked immunosorbent assay. Results The expression levels of IL-6 and IL-10 were significantly higher in the patients than in the controls. Patient's history is have negative correlation with IL-6 contents in the intervertebral disc. IL-6 contents in the extrusion intervertebral disc is higher in herniation. Patient's history is have correlation with Patient's JOA index,Patient's JOA index have negative correlation with IL-6 and IL-10. Conclusion The herniated lumbar disc have abilities of excrete pro-inflammatory of cytokines, it can stimulate excrete anti-inflammatory cytokinesIL-10 levels. Patient's history is have correlation with Patient's JOA index. Cytokines is not alone ,they react to each other , correlation with clinical findings...