The Correlation Between Interleukin-1 Receptor Antagonist Genotype And Coronary Heart Disease With Chronic Periodontitis Patients

Objective To investigate the correlation of interleukin-1 receptor antagonist (IL-1ra) genotype and chronic periodontitis (CP) in coronary heart disease (CHD) patients. Methods Genomic DNA was obtained from buccal swabs of 86 patients with CHD,of which 45 patients with moderate to severe CP, another 41 patients without CP. Genotypes of IL-1RN intron 2 VNTR was analyzed by SSP-PCR method. Then compared the differences in distribution of each genotype. Results A significant over-representation of IL-1 RN intron 2 VNTR allele 2 was found in CP with CHD group (X2=4.960, P=0.026). Conclution IL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of chronic periodontitis in CHD.