| In recent years the incidence of coronary heart disease, the mortality rate showed an upward trend, China has become a serious threat to the health of people in major diseases, in many countries the incidence and mortality rates have even more than cancer ranks first. Complex coronary heart disease risk factors, are now known to the traditional risk factors such as smoking, hypertension, diabetes, high blood lipids, such as in the clinical research importance has been attached by changing unhealthy lifestyle intervention and multiple risk factors can significantly reduce the incidence of coronary heart disease and mortality rates. But in recent years, many clinical and basic research found that about 50% of the patients with coronary heart disease do not have the traditional factors have been identified, more and more new coronary heart disease risk factors in the development of the people's attention from important role. Fibrinolysis - coagulation abnormalities caused thrombosis is an important factor, fibrinogen (Fib) is an acute-phase protein involved in blood coagulation process is thrombosis of the main components. D-dimer (DD) is cross-linked fibrin degradation products, reflected both in the fibrinolytic activity, and reflect coagulation activity. Therefore, the study of patients with coronary heart disease plasma fibrinogen, D-dimer for statistical analysis, review Exploration fibrinogen and D-dimer and coronary heart disease and the correlation of clinical significance for clinical better guidance on this Prevention and treatment of patients lay a solid foundation. This paper reviews of the hospital from July 2006 to May 2007 and coronary angiography in patients with complete information related to 114 cases, patients were selected to the standard Judkins coronary angiography to one or more coronary artery diameter stenosis≥50% of the diagnostic criteria for coronary heart disease, coronary heart disease patients were divided into group and the normal control group. At the same time will determine the degree of coronary artery stenosis Proudilit grading standards to streamline and vascular lesion count and combined divided into: (1) mild disease (≤50% of vascular stenosis, the limitations of single lesion) (2) moderate disease group (single-or two narrow tubular vascular lesions, as in a narrow 50% to 75%) (3) severe lesions (single vessel≥75% stenosis, or diffuse lesions 3). Another will be the basis of clinical symptoms of patients with coronary heart disease according to WHO 1979 ischemic cardiomyopathy on the diagnostic criteria, patients with coronary heart disease will be divided into groups of acute myocardial infarction, unstable angina group, stable angina group. Detailed records of the above-mentioned gender, age, history of hypertension, a history of diabetes and TC, TG, HDL, LDL, fasting blood glucose, and DD Fib of value, and statistical analysis, P<0.05 indicated statistical significance.The results: 1,coronary heart disease patients with plasma fibrinogen, D-dimer levels were significantly higher than the normal control group, respectively (P<0.01). 2,in the AMI patients with coronary artery disease (acute myocardial infarction), UAP (unstable angina), plasma fibrinogen and D-dimer levels were significantly higher than that of SAP (stable angina) , significantly higher than the AMI group Fib UAP group (P<0.05), and AMI group and UAP group DD level there was no significant difference (P>0.05). SAP group and the control group Fib, DD showed no significant difference (P>0.05). 3,and the UAP group AMI detection fibrinogen and D-dimer were significantly higher than that SAP group and the control group (P <0.01), while the detection of fibrinogen and D-dimer positive patients AMI and UAP group belonging. 4,the coronary artery disease group Fib and DD levels were significantly higher, severe lesions was significantly higher than that in group Fib, mild lesions group, statistical significance (P<0.05), mild lesions Fib no obvious difference (P>0.05). Light, moderate and severe lesions DD level group there was no significant difference (P>0.05). 5,coronary light, moderate and severe lesions Fib and DD positive rate was significantly higher (P<0.01), Fib severe lesions were significantly higher than that mild lesions (P<0.05); severe lesions positive rate and Fib DD and DD are two slightly higher than the ratio of positive lesions (P<0.05), mild to moderate disease group DD positive rate had no significant difference (P>0.05), Severe Fib and DD are two positive detection rate compared with no statistical significance (P>0.05). 6, multivariate logistic regression analysis showed that, Fib and DD for the independence of acute coronary syndrome risk factors, the specific results: Fib (OR=42.638, OR95% CI=9.069 to 200.451), the DD (OR=18.763, OR95% CI=4.230 to 83.230), and from the degree of coronary artery disease, both of which are severe coronary artery disease risk factors, the specific results: Fib (OR=6.657, OR95% CI=2.562 to 17.298), the DD (OR=16.802, OR95% CI=3.985 to 70.848), were statistically significant (P<0.05).Conclusion:1,patients with coronary artery disease Fib, DD levels were significantly increased, and increased with the degree of coronary artery disease and the stability of the coronary artery lesions and the degree of stenosis.2,the Joint Monitoring and DD Fib of coronary heart disease, especially for patients with acute coronary syndrome and severe coronary artery disease judgement is of great significance.
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