Research On The Rationality Of The Use Of Antibacterial Agents In Our Hospital

Objective: We investigated and analyzed the situation of antibacterial agents' application in our hospital, in order to offer pharmaceutical service effectively, promote the rational use of antibacterial agents, and lighten the economy burden of patient and society.Methods: The consumption of antibacterial agents was analyzed based on computerized information including the whole year total marketing amount of all drugs, antimicrobial agents, and the rate of antimicrobial agents. A sample of 600 inpatients cases, 180 inpatients cases hospitalized for operation and 1200 prescriptions of outpatient prescriptions from 2006.1 to 2006.12 of our hospital were randomly selected and carefully reviewed. To assess the rationality of antimicrobial agents' administration, we designed correlative tabulations to analyze the information statistically of the selection and usage of antibacterial agents in hospitalized patients, the regularity of the antibacterial agents used during operation, the similarity and differences of antibacterial agents used in out-patients department and sickroom, the similarity and differences of inpatients with and without surgical operation. At the same time, we analized the situations of infections in hospital, the pathogenic bacteria detected and the rate of bacteria culture and we also introduced Defined Daily Dose for rationality assessment.Results: The amount of antibacterial agents consumption took a rate of 24.23% in all drugs costs in the whole year we studied, while the rate was 23.19%,31.15% and 26.84% respectively of out-patients, inpatients with and without operations. Antibacterial agents was used extensively, involving 8 classes and 29 kinds. The average use rate of antimicrobial agents in the whole hospital was 59.9%, while the rate was 44.83%, 100% and 78% respectively for out-patients, inpatients with and without operations. Combined antimicrobial agents administration took a rate of 52.28%, following a 75% and 92.78% of inpatients with and without operation. All cases was given antimicrobials over the rational time for the operational patients. Additionally, we found 12 cases infections infected in hospital, 9 cases delayed allergy, no cases had taken pathogenic bacteria detection and culture.Conclusion: The unreasonable phenomenon of the antibacterial agents used in our hospital is extensive. The rate of antibacterial agents use was high. There are a lot of un-rational combined use. The drug was dissolved with incorrect solvent and was not administrated in a properly dosage and regimen. A large difference in the use of antibacterial agents was found between out-patients department and inpatient department. The situation was worse for the inpatients of surgical operation than the hospitalizations not performing surgical operation. The usage of the antibacterial agents needs further to improve in our hospital over the years to come. The hospital must pay more attention on this situation, and establish a serious regulation to improve the rational use of antibacterial agents. The health workers need to study more knowledge. The president of the hospital should enhance the management for clinical work, especially for the rational use of antibacterial agents for prophysis in operation ward, pay more attention on the bacterial culture, encourage the pharmacist to provide more pharmaceutical services. Only in this way, the bacterial resistance and high medical cost should be reduced, and achieve rational use of antibacterial agents.