| Objectives To explore the effects of carbamazepine (CBZ )to nocturnal sleep architecture and cognitive functions in patients with temporal lobe epilepsy (TLE)。Methods 30 patients with temporal lobe epilepsy were collected, who had no evidence of anatomic brain lesion on neuroimaging and had never been treated with AEDs, Polysomnography (recordings) was performed at baseline,1 week(starting at a dose of 200mg daily and increasing over 1 weeks 400mg daily) and 12 weeks(maintaining at a dose of 600mg daily) after administration of carbamazepine. The findings were compared with those of sleep parameters of 1 week and 12 weeks to baseline. The cognitive functions are scored are performed before and after 12 weeks of treatment with carbamazepineResults with carbamazepine 1 week treatment provoked a reduction a of rapid eye movement (REM) sleep(P<0.05),which weren't significant in 12 weeks treatments (P > 0.05);at the same time ,we also observed that treatment of carbamazepine acute (1 week) therapy provoked an increase of slow wave sleep(SWS) in PSG (P<0.05),for which changes persisting in 12 weeks (P<0.05);however, no significant changes were observed in the cognitive functions scores(P>0.05).Conclusions we conclude that carbamazepine has negative effect on REM during acute administration but chronic treatment does not significantly modify nocturnal sleep. In term of SWS increasing ,so we conclude carbamazepine can improve sleep after chronic treatment;and does not change cognitive functions.For these reasons it could be an important drug for improving life quality of epilepsy patients.
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