The Research On The HRV Of Cerebral Infarction Patient With Insomnia

PurposeObserve and measure the parameters in each frequency table of HRV (Heart Rate Variability)under the condition of pure cerebral infarction and under the condition of cerebral infarction withinsomnia respectively. Explore the significance of insomnia that would help to judge the conditionof cerebral infarction. Study and estimate the effective index that would judge the level of insomniaand cerebral infarction in order to provide the supervisory means that would help to assess theprognosis in early stage and direct the treatment.MethodsAccording to the scores of the Pizerburg Sleeping Quality Index (PSQI), regarding the plus 7as the insomnia, set up no insomnia after cerebral infarction group (pure cerebral infarction groupn=30, male 16, female 14), insomnia after cerebral infarction group (with insomnia group n=30,male 16, female 14), and no insomnia no cerebral infarction group (healthy comparing group n=30,male 15, female 15). Each case will measure the PSQI, NIHSS and other routine examinations.HRV examination: with the WG-MD-ANSA01 produced by Taiwan We-Gene TechnologyCompany, take the records of heart rate variability. The unit is 5 minutes. Get the continuousnormal R-R, which will be illustrated by the software in the machine, and then get the parameters ofeach frequency table of HRV.Analyze the differences of HRV parameters between cerebral infarction with insomnia andpure cerebral infarction, and the relationship between the parameters and insomnia, condition of thedisease. Take logarithm of the abnormal index. Use t to examine the differences among groups; usesolo-factor linear programming analysis to analyze the relatives of factors; use F to examine therelative coefficient notable character. ResultsThe parameters of HRV will change for the pure cerebral infarction, and for the cerebralinfarction with insomnia the change will be more obvious: the decreasing of the autonomic nervegross, RR, VAR, which reflect the total autonomic nerve, is very different; the differences of the HF,which reflect the parasympathetic nerve, is very different; but LF%, HF%, LF/HF that reflect thesympathetic nerve do not have obvious differences. With insomnia group's PSQI and NIHSS areoutstanding higher. Relatives demonstration: some autonomic nerve change HRV parameterindexes are obviously relative with the PSQI and NIHSS for the cerebral infarction: age,LF%,,LF/HF,PSQI is directly relative with the NIHSS, VLF,LF,HF,Var,RR,TP,HF%) are inverselyrelative; PSQI is notably relative with the NIHSS.DiscussionClinically, the prognosis of the infarction patient with insomnia is not well. The traditionalindex of PSQI and NIHSS has shortcomings and the large application is limited.On the basis of insomnia, this experiment sets pure cerebral infarction group, with insomniagroup and healthy comparing group. With the traditional NIHSS and PSQI as the golden criteria,HRV in each group is tested respectively, and much information about the autonomic nerve systembalance status is got. Compare the data ,in each group, and get the statistical analysis results:insomnia is relative with the condition of cerebral infarction (nerve function loss condition) and thechanges of autonomic nerve (HRV).HRV of pure cerebral infarction group (compared with the healthy group): the autonomic nervegross decreases in the pure cerebral infarction group, the activity of parasympathetic decreases andthat of sympathetic increases. With insomnia group (compared with the pure cerebral infarctiongroup): the autonomic nerve gross decreases in the pure cerebral infarction group, the activity ofparasympathetic decreases and that of sympathetic increases, with PSQI and NIHSS increasingoutstandingly. LF decreases obviously.Relativity: 1. for the cerebral infarction patient with insomnia, the condition of nerve functionloss is relative with the insomnia; 2. for the cerebral infarction patient, many indexes of theautonomic nerve changes (HRV) are obviously relative with the PSQI and NIHSS, and the relativity of many indexes is strong which may well represent NIHSS and PSQI.Conclusionâ‘ Insomnia is most directly relative with the condition of cerebral infarction, and the changesof HRV are obvious.â‘¡HRV analysis is easy and practical,â‘¢Chosen HRV parameters can be usedas the indexes to estimate the insomnia and nerve loss, and have some clinical directory significancefor assessing the cerebral infarction autonomic nerve loss and for the judging of the patient'scondition.