A Clinical Analysis Of Altered Interleukin-6 Levels In Alcoholic Liver Disease

ObjectiveWhen hepatic lesion resulted from alchol presented the increaing tendency year byyear,alchol became the second etiological factor resulting in hepatic lesion excludingviral hepatitis. Cytokine has significant effect to eailier hepatic lesion on account ofalchol which include participating in the occurrence of hepatic inflammation, apopto-sis of hepatic cell, hastening oxyen exhausted,as well as the intimate relationship withhepatic fibrosis and liver cirrhosis.as a response factor in acute stage,IL-6 participate inthe course of histogenic immunity and pathematological reaction, inflammation in liverwhich induce hepatic tissue damage.our study compare the IL-6 level of blood serumwith the patient in different stages of alchol hepatic disease,and between which andother liver function result a dependablity analysis made .accordingly, we approach therelationship with IL-6 and activity of inflammation ,extent of lesion, the meaning ofdynamic states in the process of inflammating damage.MethodsPatients with patient in the ALD were enroled in shen yang infectious diseasehospital from 2004,June～2005,October including 38 cases in AF and 36 cases in AH,38cases in AC. All above-mentioned cases accorded with diagnostic criteria institutd byChinese Medical Association. 12 cases were involved in control group excluding thedisease with regard to virus hepatitis and liver cirrhosis,diabetes mellitus,kidneyfailure,coronary artery disease,acute pancreatitis. All subjects were drawn 4ml venousblood on an empty stomach in morning, detection of IL-6 in blood serum adopt ELISAmethod of double-antibody which proceed was operated according to description. accoding to the OD number of cases which was carried out with microplate reader,wefind out corresponding concentration. It is firstly indentified that IL-6 level in bloodserum in the control group and expedment group including AF,AH,AC accord withnormal distribution,then data in groups were compare by q test of ANOVA.IL-6 indifferent phase of ALD make a corrlation analysis of pearson with main data of liverfunction such as ALT,AST,CHE,ALP,GGT,TBIL.ResultsCompared in IL-6 level in different stage of ALD, IL-6 level in AH and AC has asignificant difference to the control group,and the level in AH compared to AC has nosignificant difference as well as AF to the control group.IL-6 level in blood serum inAH is positive correlation to GGT, IL-6 level in blood serum in AC is neagtivecorrelation to CHE,ALB of liver function.ConclusionIn different stages of ALD,IL-6 level has discrepancy.IL-6 level in patients withAH and AC increase significantly with IL-6 level of health body.Compared with healthbody,IL-6 level in patients with AF have no chang .Otherwise, IL-6 level in bloodserum has invariable relationship with the extent of hepatic lesion in different stage ofALD.IL-6 level in AC is relevant to main date of liver function such as ALB,CHEwhich indicate extent of liver chronic lesion.IL-6 level have a relationship to GGT inAH.