The Effect Of Adherence Intervention For People With Schizophrenia And Their Family Caregivers

At the present time, the most useful treatment of schizophrenia is utilizing antipsychotic drugs. However, nearly 50% patients with schizophrenia were noncompliant. High replase rate, heavy medicare burden, bad quality of life and heavy burden carried by caregivers often happened in these noncompliant patients. Since 1980s, researchers started to pay more and more attention to this problem. There were much more differences between the results of researches which had been done before, because there are lots of factors which influenced compliance and the patterns of intervention were simplex. Therefore, more and more scholors pointed out integrated intervention/therapy may be useful. This study aimed to analysis the effectiveness of compliance therapy which based on motivation interviewing dilivering to inpatients with schizophrenia and provide evidence for clinical staff.Objective: This study aimed to develop an pattern of compliance therapy for psychiatric clinical nurses and test its effectiveness within a group of people with schizophrenia and their family caregivers in short term.Method: In one of the special psychiatric hospitals on top grade, eight normal wards were divided into intervention wards and control wards. 35 patients and their family caregivers who met the recuited cretieron participated in the study and assigned to the intervention group (17 patients and families) and the control group (18 patients and families). After the dosage level of drug was stabled, the intervention group and the control group separately received "compliance therapy + health education" and "health education", all of patients were followed up after discharge at 1 month and 3 month. According to the conceptual framework, drug compliance, psychiatric symptoms (PANSS), insight and attitude to drugs (ITAQ), social function (WHO DASâ…¡), treatment-emergent signs and symptoms (TESS), medical cost, patients' and families' quality of life will be measured. Results: Though compliance therapy, patient's drug compliance, insight and attitudes to treatment improved significantly, psychiatric symptoms were alleviated significantly, side effects of antipsychotic drugs and it's impact on patient were declined significantly and clinical outcome impoved significantly during the follow-up of three months. However, patient's social functions and quality of life, families' quality of life were not improved significantly after compliance therapy during the follow-up of three months. Moreover, the hospitalized cost of the intervention group, is higher than the controlled, but there is no significant difference between them.Conclusion: In this randomized controlled trail, inpatients with schizophrenia benefited from compliance therapy. Long-term follow-up should be needed to discover the effects of compliance therapy.