Change Of Contens Of Plasma C-Type Natriuretide And Dendroaspis Natriuretic Peptide In Essential Hypertension

Objective:To investigate the change of plasma C-type natriuretic peptide and dendroaspis natriuretic peptide levels in essential hypertension.Methods:Twenty-one essential hypertensive patients and twenty-one hypertensions with left ventricular hypertrophy were recruited with 21 normal persons served as healthy controls. CNP and DNP concentrations were measured with ELISIA. Echocardiography and Bioz.com digital non-invasive hemodynamic monitoring were obtained in all patients.Results:(1)The plasma CNP and DNP levels in hypertension group were higher than that in healthy control group. The plasma CNP and DNP levels in the group of hypertensions with left ventricular hypertrophy were higher than that in hypertension group and healthy control group.(2) There was no difference in the plasma CNP and DNP levels of different grades of essential hypertensive patients. (3) The concentration of CNP in essential hypertensive patients was positively related with IVST, LVMI and TFC. The concentration of DNP in was positively related with LVMI, CO, CI, and inversely related with SVR, SVRI.Conclusion:The plasma CNP and DNP levels in essential hypertensive patients were increased. And the plasma CNP and DNP levels in hypertension group were higher than those in the group of hypertensions with left ventricular hypertrophy.