| Objective To investigate whether the number of circulating CD14+KDR+ cells correlate with the extent or severity of coronary artery disease and cardiovascular risk factors.Background There is now growing evidence that among circulating cells with angiogenic capacity there are at least two subpopulations with distinct marker phenotypes and potentially distinct roles, i.e. , CD34+KDR+ cells and CD14+KDR+ cells. Both types of EPCs show comparable in vivo vasculogenic capacity, but the latter is more abound in quality. Previous studies have suggested an inverse relationship between levels of circulating EPCs and the presence of CAD or cardiovascular risk factors, whereas other studies have observed inconsistent results. However, these studies did not distinguish two types of EPCs or only studied CD34+KDR+ cells. Thus, the relationship between the level of circulating CD14+KDR+ cells and the development of, presence of, and severity of CAD remain unclear. Methods 90 patients who underwent coronary angiography were enrolled. Physical examination and blood tests were performed to assess the disease severity and cardiovascular risk factors; acute ischemic events which including UA, NSTEMI and STEMI within the past 2 weeks were registered. Circulating CD14/KDR double positive cells were detected by FACS.Results The number of circulating CD14+KDR+ cells was not significantly different in patients with normal coronary artery compared with those with stable CAD or acute ischemic events. Neither was there any association between the severity of coronary disease or acute ischemic events and the number of circulating CD14+KDR+ cells. The number of circulating CD14+KDR+ cells does not appear to be associated with major cardiovascular risk factors too.Conclusions The number of circulating CD14+KDR+ cells was not significantly correlated with the severity of coronary disease, acute ischemic events and cardiovascular risk factors.
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