Relationship Between CD14 And Human Cytomegalovirus Infection And Progression Of Coronary Heart Disease

Objective To explore the relationship between serum soluble CD14(sCD14) level and human cytomegalovirus(HCMV) infection and progression of coronary heart disease(CHD).To evaluate their relationship among inflammation,infection and CHD. This may contribute to prevent,diagnosis,treat and prognosis coronary heart disease in clinic.Methods The serum sCD14 and HCMV-IgG were determined by enzyme-linked immunosorbent assay(ELISA).One handrand and twenty patients with CHD were divided into three groups,included acute myocardial infarction(AMI),stable angina pectoris(SAP),and unstable angina pectoris(UAP).Forty healthy subjects server as controls.Results The serum levels of sCD14 and HCMV-IgG in the CHD patients were higher than that of the control group(t=15.75,14.50,P＜0.01).There were significant difference in the serum levels of sCD14 and HCMV-IgG among the groups of AMI, UAP,SAP and control(F=132.94,49.07,q=9.70-27.58,P＜0.01).There were significant difference in the serum levels of sCD14 and HCMV-IgG among the groups of AMI,UAP and SAP(F=132.94,49.07,q=2.92-17.88,P＜0.01,0.05),expecial the AMI has the most signifcantly increased.There was a correlation between the elevation of sCD14 and HCMV-IgG in the AMI group(r=-0.45,P＜0.01).Conclusion The elevated serum level of sCD14 and HCMV infection were closely associated with CHD,which might be used to predict the disease.