Experimental Study Of The Effects Of Baizhu Volatile Oil On Antitumor Multiplication And Anti-Metastasizing

Objective: Discuss thee effects of Baizhu Volatile oil on anti- tumor multiplication and anti-metastasizing and its related mechanism. Methods: To research Baizhu volatile oil 'effects of anti-multiplication: We adopted the method of Kun ming pedigree mice axilla subcutaneous tissue vaccinate, made H₂₂ liver cancer and S₁₈₀ sarcoma transplanting models, Observes the effects of anti-multiplication; the fluorescence immunity organization research method examined the mouse transplant nature S₁₈₀ entity lump organization p53(突变型) and the bcl-2 expression. To research Baizhu volatile oil 'effects of anti-metastasizing: We adopted the method of Kun ming pedigree mice caudal vein and under fingernail packing leather vaccinate, made H₂₂ liver cancer cells blood route metastasis models and lymph route metastasis models; Observes the effects of anti-metastasizing; ELISA examination to exame the MMP-9 expression in blood route and lymph route metastasis model mouse'blood serum. Results: The effects of the treated groups were better than the contract group. The study of its mechanism showed that in the S₁₈₀ lump organization apoptosis-associated gene p53, the bcl-2 expression the treated groups is lower than the model group; in the blood serum the MMP-9 expression the treated groups is lower than the model group comparison group. Conclusion: Baizhu volatile oil has the double effects of anti- tumor multiplication and anti-metastasizing.