The Relationship Between The Prognosis Of Multiple Sclerosis Patients And The Peripheral Blood CD4～+CD25～+T Regulatory Cells

The relationship between the prognosis of multiple sclerosis patients and the peripheral blood CD4~+CD25~+T regulatory cellsPurpose: to approach the relationship between the prognosis of multiple sclerosis patients and the peripheral blood CD4~+CD25~+T regulatory cells.Methods: The R-R type of MS patients were brought into this study by the diagnostic criteria of National Multiple Sclerosis Society (NMSS), 2001. The study includes two portion, the first one: the percentage of peripheral blood CD4~+CD25~+T regulatory cells were analysised the difference among the MS patients, acute cerebral accident (ACA) patients and the health ones (HO) by the K-W test. Another one: The neuro-function of MS patients were scored through NIH Stroke Scale prior to hospitalization and after admission. The relationship between the prognosis and four factors of MS patients were analysised by multiple linear regression, which were the percentage of peripheral blood CD4~+CD25~+T regulatory cells, gender, age and bacterial infection on admission whether or not.Results: It was lowest for the percentage of peripheral blood CD4~+CD25~+T regulatory cells of MS among the three groups. It was disadvantage to the prognosis of MS for the decrease of the percentage of peripheral blood CD4~+CD25~+ T regulatory cells, without any affect for the others factors.Conclusion: The number of CD4~+CD25~+T regulatory cells in R-R type of civil MS patients was significantly less than control groups. It is a protective factor to MS for CD4~+CD25~+T regulatory cells, which is inverse correlation with prognosis.