Association Between Estrogen Receptor-β Gene Polymorphisms And Systemic Lupus Erythematosus In Guangxi Han Ethinic Women

Objective:To investigate the distribution of estrogen receptor—β(ERβ)gene polymorphisms in female patients with systemic lupus erythematosus(SLE)in Guangxi province(all Han ethinic),and discuss the relationship between ERβgene polymorphisms and it's clinical presentations.Methods:RsaⅠand AluⅠrestriction fragment length polymorphisms of ERβgene were performed in 78 female patients with SLE and 100 female controls by using PCR-RFLP technique.The relationship of different ERβgenotype and their clinical presentations was analyzed.Results:There are no significant differences in frequencies of genotype and allele of ERβbetween patients with SLE and controls.But,the frequency of the RR genotype was significantly higher than the others in patients with LN,and so did the Aa genotype in patients with erythema on cheeks.Conclusions:There are no significant differences in frequencies of genotype and allele of RsaⅠand AluⅠin ERβbetween female patients with SLE and female controls in Guangxi province(all Han ethinic), but the RR genotype may be associated with the susceptibility of LN in female patients,and the probability of this kind of clinical presentation of SLE—erythema on cheeks,may be related to Aa genotype.