| Objective: The aims of the study were to assess the accuracy and feasibility of the mass and function of the left global and regional ventricular by real-time dimensional (RT-3DE) echocardiography, to quantify the changes of the mass and function of the left global and regional ventricular by RT-3DE after myocardial infarction, to analyze the relation between myocardial mass and cardial function, and to evaluate the clinic application of measurement of mass by RT-3DE.Material and Methods:The study were performed in 20 control subjects (group A),25 patients with acute myocardial infarction (group B) and 21 patients with old myocardial infarction (group C). All subjects were validated by coronary angiograhy (CAG). Two dimensional echocardiography(2DE) and RT-3DE were performed in all subjects .Left ventricular mass index(LVMI), end–diastolic volume(EDV). end-systolic volume (ESV) and ejection fraction(EF) were measured by biplane Simpson's method. According to the 16 segments model formulated by American Society of Echocardiography, the wall motion were observed and its score index were calculated. The left ventricular global and regional myocardial mass, EDV, ESV and EF were measured with 8 plane method by TomTec Cardio-View and 4D-LV analysis software offline. The relation between myocardial mass and cardial function were analyzed with linear regression.Results: (1) The global differences in groupA were not significant between the results obtained by TR-3DE and 2DE. The results obtained by 2DE were lower than those obtained by RT-3DE (except EF) in group B and group C, especially in group C (P <0.01~0.05).(2)The results obstained by RT-3DE:①The mass of left global ventricular and the basal, middle, apical level were significantly higher than those in group A, (except the apical level in group B) especially in group OMI. LVMI and Sectional mass index(SMI) were significantly increased in group C(P <0.01).LVMI and SMI in group C were significantly higher than those in group B.②LVESV was enlarged and LVEF was decreased in group B and group C(P <0.01). Compared with group B, LVEDV in group C was more significant increased than that in group A(P <0.01). LVEDV and LVESV in group C were significantly increased than those in group B, especially LVEDV (P <0.01).③Regional EDV (rEDV) and regional ESV(rESV) of MI segments suggested significant increased and rEF were decreased in group B and group C, especially in group C(P <0.01). Compared with those of normal segments and non MI segments.The rEDV, rESV and regional EF(rEF) of MI segments were not significant differences between group B and group C. The rEDV, rESV of non MI segments in group C were higher than group A (P <0.05), rEF of non MI segments in group C was lower than that in group B (P <0.05).④Sectional EDV(SEDV) and Sectional ESV(SESV) of the basal ,middle, apical levels were higher and SEF were lower than those in group A(P <0.05,P <0.01), Contrast to group B,SEDV in group C were significant higher(P <0.01), and Sectional EF( SEF) of the apical level in group C were lower (P <0.05).⑤LVMI showed good agreement between group B and group C with LVEF (r=-0.66,-0.73 P<0.001); the correlation between LVMI and WMSI were good in group B and group C(r=0.70, 0.79 P<0.001),SMI highly correlated with SEF in different LV level in both group (r=-0.63,Vs-0.72, -0.53 Vs -0.69, -0.44 Vs -0.55,P <0.001).Conclusion:RT-3DE can accurately reflect the change of global and regional myocardial mass and function in different period after MI, It had important clinic value for evaluating myocardial mass.
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