Effect Of SOD And LPO In The Peripheral Blood And Clinical Research On Efficacy Of Acute Exacerbations Of Chronic Obstructive Pulmonary Disease (AECOPD) With The Management Of Clearing Away Heat-evil And Resolving Phlegm

Chronic obstructive pulmonary disease(COPD) is a disease statecharacterized by airflow limitation that is not fully reversible. Theairflow limitation is usually both progressive and associated with anabnormal inflammatory response of the lungs to noxious particles or gases.Patients of COPD usually have chronic cough, sputum production, air hungeror dyspnea, asthma and chest distress. The medicine workers pay more andmore attention to COPD which owe to a great deal of COPD patients, highcase fatality rate and weighty economy burden. This article summarize therecordation about COPD in the archaic Chinese medicine literature, theprogress of modern Chinese medicine in the study on COPD, the canonicalprevention and cure for COPD, progress of modern medicine in the studyon COPD, the connection between SOD, LPO and COPD, and so on. On the basisof the above summarization, we probe into the curative effect on AECOPDof clearing away heat-evil and resolving phlegm in thisantitheses, prospective study so as to provide scientific evidence fortreating COPD with the management of clearing away heat-evil and resolvingphlegm.ObjectiveTo observe the curative effect on AECOPD with the management ofclearing away heat-evil and resolving phlegm by analyzing the symptom,sign, blood gas analysis, spirometry, the level of SOD and LPO in theperipheral blood.MethodSixty hospitalized AECOPD patients (stageâ… -â…¢) with retention of phlegm and heat syndrome in the lung in TCM are randomly divided into twogroups, the trial group and the control group. The patients of trial grouptake the Chinese medicine decoctions which have the efficacy of clearingaway heat-evil and resolving phlegm(qianjin weijing decoction plusothers), and simultaneously accept conventional therapy of the westernmedicine same as the control group (controllability oxygen treatment,bronchodilators, antibiotic, expectorants). The period of treatment is10 days. To compare the result of two groups by analyzing clinical symptomand sign, blood gas analysis, spirometry, the level of SOD and LPO inperipheral blood.ResultClinical symptom and sign:After the treatment, melioration of clinical symptom and sign in bothgroups have significant difference(P＜0.01 or P＜0.05). Compared withthe control group, melioration of the trial group, such as cough, sputumproduction, dyspnea, rhonchi and rale is greater, showing significantdifference(P＜0.01 or P＜0.05). The above result show that therapy of twogroups both can help COPD, and the trial group is better than the controlgroup.Blood gas analysis:The melioration of PaO₂, PaCO₂ have significant difference in bothgroups. Compared with the control group, melioration of the trial groupis greater and has significant difference(P＜0.01). So we can see that thetherapy of both groups can help to improve the indexs of blood gas analysis,and the trial group is superior to the control group.SOD and LPO in the peripheral blood:SOD in the peripheral blood of both groups increase, and LPO reduce,showing significant difference(P＜0.01). And Both of the index differ moregreatly in the trial group. So we can see that the effect of the trialgroup on increasing SOD and reducing LPO in the peripheral blood is moresignifiant than the one of the control group.ConclusionThe management of clearing away heat-evil and resolving phlegm canhelp AECOPD. It can improve clinical symptom and sign, remedy the stateof anoxia and carbon dioxide retention, increase SOD and reduce LPO in the peripheral blood so as to accelerate rehabilitation of COPD patients.