Chinese Medicine And Clomiphene For Dysfunctional Ovulatory Acyesis: A Systematic Review

Objective Evaluate therapy validity of dysfunctional ovulation acyesis by Chinese medicine adds clomiphene and clomiphene only.Method Using Cochrane systematic method to index CBM (Chinese biomedicine literature)database(1978-2006.9), VIP Chinese science and technology periodical database(1989-2006.9), CNKI full text periodical database(1994-2006.9), MEDLINE CD database (1956-2006.9), EMBASE CD database(1974-2006.9) and randomized controlled trial registration database of the Cochrne library by computer system. Manual work indexed reference documents of Chinese magazine and proceedings about acyesis, in order to collect the randomized and semirandomized controlled trial tries the published and unpublished rele vant Chinese medicine adds clomiphene and clomiphene only for dysfunctional ovulat ion acyesis. According bring into and exclusion standard choosing the documents, the methodology quality evaluation standard of recommended by Cochrne cooperation net, to evaluates the curative effect of Chinese medicine adds clomiphene and clomiphene validity for dysfunctional ovulation acyesis through the guide line of gestation rate/conceive rate,ovulation rate, basal animal heat,cervical mucus grad ed, and endometrium ply. Bring quality analysis for bring into research through using Revman4.2.8 software.Result Indexing out 13 aticles Chinese literature totally, according bring into and exclusion standard to bring into 13 experiments that are 1555 example patient at last. Through the methodology quality evaluation, "B" class is 3 articles, "C" class is 10.Evaluation's guide line is that gestation rate is 13articles, ovulation rate is 12,basal animal heat is 4,cervicle mucus is 4,endometrium ply is 5. Showing as a result through the analysis: gestation rate ofthe Chinese medicine adds clomiphene is[RR 1.68 ,95% CI (1.50,1.89) ](P<0.00001) ;ovulation rate is[RR 1.19, 95% CI (1.12, 1.26 ) ](P<0.00001) ;The basal animal heat is[RR 1.27, 95% CI (1.09 , 1.46) ](P=0.001) ; cervicle mucus is [RR1.71, 95% CI (1.38 , 2.12) ] (P<0.00001) .Conclusion There are markedness difference in curative effect by Chinesetraditional medicine adds clomiphene and clomiphene only for dysfunctionalovulation acyesis.Because the collection literature is not high quality and the proof is not strong enough, it is needed to be approved by the big swatch and the high quality multi-centers controlled trial further by randomized and double blind. Its side effect evaluation will be evaluated in later research.