The Clinical Analysis Of Fractionation Gamma Knife Radiosurgery Treatment For Functional Pituitary Adenoma

Objective: To investigate and analysize the therapeutic efficacy offractionation Gamma knife radio surgery in the treatment of functional pituitary adenomas.Methods: Ninety-five cases of hypersecreting pituitary adenomas weretreated with OUR-RGS/Arotating Gamma kife fractionally. Of this cohort,there were 41 patients harboring prolactinomas, 23 patients with GH-secreting adenomas, 15 of all cases with cushing diseases. The other 16 cases with complex secretory carcinomas. Single Gamma kife treatment marginal doses were with an average of 11.5Gy. The isodose curve is between 35% and 55%.The interval time between the two treatment is ranged from 10 days to 19 days.Results: All patients had been followed up from 3-54 months (averaged43.2 months). To analysize the tumors volume and secretary function .the tumor's local control rates was at 94.7%. Of the 58 patients(61.1%) had normalization of hormone level and 29 patients(30.5%) experienced decreasing hormone level.21 patients experienced refractory headache 3-10 months later after GKS.17 patients with greater volume tumor were found transient vision decline . Of the 9 patients had been found new declining-hormone 2-3 years later. Other side effects had not been found during the follow-up time .Conclusion: Short-term fractionation gamma knife treatment for functionalpituitary adenoma is effective both tumor growth control and biochemical remission...