Plasma Concentrations Of Interleukin-20 In Acute Coronary Syndrome And Its Clinical Significance

Objective: To examine the plasma concentration of interleukin-20 inACS and to investigate the relationship between Interleukin-20 (IL-20) andCRP, LDL-C, clinical severity of coronary artery disease.Methods: 72 patients admitted in the second Xiangya hospital,including 23 patients with unstable angina and 32 patients with acutemyocardial infarction (AMI), 17 patients as control. The plasmaconcentration of interleukin-20 was tested by ELISA, and the blood lipids,blood sugar, CRP, myocardial enzyme were also examined. Gensiniscoring system was applied to evaluate the severity of the stenosis ofcoronary arteriesResults: Plasma concentration of IL-20 was significantly increased inthe Acute coronary syndrome groups compared with the control groups(127.03±22.36 pg/mL vs 7.69±1.69 pg/mL, P＜0.01). No difference ofIL-20 concentration was found between patients with unstable angina andpatients with acute myocardial infarction. Plasma IL-20 concentrationsignificantly correlated with increased LDL-C(r=0.695, P＜0.01),CRP(r=0.546, P＜0.01)and the coronary artery Gensini score (r=0.652,P＜0.01)Conclusions: Plasma concentration of IL-20 was increased in patientswith acute coronary syndrome and been shown positively correlated withthe concentration CRP, LDL-C and the stenosis severity of coronary artery.