The Serum Level Of Interleukin-38 In Patients With Non ST-elevation Acute Coronary Syndromes

Objective: To investigate the serum level of interleukin-38(IL-38)in patients with non ST-elevation acute coronary syndromes and to find the relationship of hypersensitive c-reactive protein(hs-CRP),GRACE score and Gensini score with IL-38.Methods: 58 patients with coronary heart disease as the experiment group;In the meantime,20 patients had chest pain with negative coronary artery angiography as the control group.The baseline clinical data were collected including gender,height,age,weight,,hypertension history,diabetes history,smoking history,family history,low-density lipoprotein cholesterol(LDL-C),serum total cholesterol(TC),triglyceride(TG),lipoprotein?,apolipoprotein B,fasting plasma glucose(FPG),serum creatinine,blood uric acid,pro-BNP,hypersensitive c-reactive protein(hs-CRP),white blood cell and heart ejection fraction.The serum levels of IL-38 of patients were measured by enzyme linked immunosorbent assay(ELISA).According to clinical manifestations,all cases were divided into three groups:control group,stable angina pectoris(SAP),non ST-elevation acute coronary syndromes group(NSTE-ACS).Meanwhile we compared the level of hs-CRP and IL-38 in three groupsAccording to GRACE score,patients with non ST-elevation acute coronary syndromes group(NSTE-ACS)were divided into two groups: low-risk group(GRACE score?108)and high-risk group(GRACE score>108).Meanwhile we compared the level of hs-CRP and IL-38 in two groupsAccording to Gensini score,patient with coronary heart disease were divided into two groups:non-severe CAD group(Gensini score?30)and severe CAD group(Gensiniscore>30).Meanwhile we compared the level of hs-CRP and IL-38 in two groups.All analyses were done with statistical software analysis,P<0.05 was considered significant.Results: Hs-CRP in three group were 0.35±0.25mg/L ? 0.58±0.53mg/L ?3.90±2.05mg/L,IL-38 in three group were 90.98±26.24 pg/ml?91.35±17.68 pg/ml?107.37±20.52 pg/ml.Hs-CRP in control group and SAP group were lower than that in NSTE-ACS group(P<0.05).The conclusion of IL-38 was same with hs-CRP.According to GRACE score,hs-CRP in low-risk group was lower than that in high-risk group(1.26±1.23mg/Lvs 7.30±5.15 mg/L,P<0.05);IL-38 in low-risk group was lower than that in high-risk group(100.63±23.47 pg/mlvs116.03±11.55 pg/ml,P<0.05).According to Gensini score,hs-CRP in non-severe group severe CAD group was3.08±2.56 mg/L,that in severe group severe CAD group was 3.54±3.39mg/L,there was no significant difference between the two groups.IL-38 in the two groups were104.69±21.81pg/ml ? 104.54±20.30 pg/ml,IL-38 in the two groups still have no difference.According to correlation analysis,the level of IL-38 has positive correlation with pro-BNP,hs-CRP and GRACE scores,but has no correlation with Genisi score.Conclusion: The serum level of interleukin-38(IL-38)in patients with non ST-elevation acute coronary syndromes was highly increaded;what's more,IL-38 has positive correlation with hs-CRP and GRACE score;so as a new anti-inflummatory cytokine,IL-38 may reflect the degree of myocardial damage.