Expression And Clinical Significance Of VCAM-1 In Epithelial Ovarian Carcinoma

Objective To study the correlation of expression of VCAM-1 (Vascular cell adhesion molecule-1) in tumor of epithelial ovarian carcinoma(EOC) and circulating sVCAM-1 (soluble vascular cell adhesion molecule-1) with angiogensis ,tumor metastasis ,clinical ,histological and pathological parameters.Methods Specimens from 61 epithelial ovarian carcinoma,56 benign ovarian tumors and 40 normal ovarian tissue , Image analysis with the methods of immunohistochemistry followed. The correlation between VCAM-1 expression and pathological characteristics of epithelial ovarian carcinoma was studied, Meanwhile, the serum levels of soluble VCAM-1 were measured with enzyme-linked immunoadsorbent assay(ELISA) in 61 patients with ovarian carcinoma and 56 patients with benign ovarian tumors preoperatively and postoperatively. The correlation between sVCAM-1 expression and pathological characteristics of epithelial ovarian carcinoma was studied.Results VCAM-1 was expressed highly not only in the membrane of some epithelial ovarian carcinoma cells but also related with angiogensis ,tumor metastasis . Serum concentration of VCAM-1 in the patients with epithelial ovarian carcinoma was significantly higher than in comparison the group of benign ovarian tumors subjects(P＜0.01) ,and related with classification and histological and pathological parameters stage ,and the level of postoperative sVCAM-1 was reduced significantly on contrast to preoperative (P＜0.01).Conclusions VCAM-1 may play a crucial role in the angiogenesis and metastasis ,and sVCAM-1 may be considered as an effective diagnostic and prognostic factor. Postgraduate student: xiu-Juan Chui (Gynecology)Directed by Associate prof. zhu-mei Chui...