Serum Level Of Soluble Intercellular Adhesion Molecule-1 (sICAM-1) And Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) And Its Clinical Sighnificance In Patients With Viral Hepatitis B

Objective: To further explore the relationship between Type I hypersensitivity reaction and the mechanism of the viral hepatitis B through the research of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1( sVCAM-1) levels in serum in patients with viral hepatitis B related to Type I hypersensitivity reaction and the damage of liver cells, and therefore, provide new theory for the perfection of the immunological mechanism of hepatitis B, especially acute hepatitis B. Methods: Serum sICAM-1 and sVCAM-1 levels were measured in 45 patients with viral hepatitis B and 15 normal cases using double antibody sandwich ELISA method. AST and ALT levels were studied using omni automatic biochemistry analyzer and its correlation with sICAM-1 and sVCAM-1 were observed. Results: (1) The sICAM-1 and sVCAM-1 levels of 7 acute hepatitis B were significantly higher than that of the normal cases (P<0.01, P<0.01). (2) The sICAM-1and sVCAM-1 levels of 38 chronic hepatitis B were also significantly higher than that of the normal cases (PO.01, PO.01). ? The sICAM-1 and sVCAM-1 levels of 13 cases moderate chronic hepatitis B were significantly higher than that of 16 cases mild chronic hepatitis B (P<0.01, PO.01). ? The sICAM-1 and sVCAM-1 levels of 9 serious chronic hepatitis B were significantly higher than that of the group of mild chronic hepatitis B (P<0.01, P<0.01). ? Levels of sICAM-1 were significantly positively correlated with serum ALT and AST (r = 0.743, PO.01; r = 0.660, PO.01). ? Levels of sVCAM-1 were significantly positively correlated with serum ALT and AST (r = 0.589, PO.01; r = 0.621, PO.01); In conclusion, sICAM-1 and sVCAM-1 levels in patients with acute hepatitis B were most remarkably increased, and then serious chronic hepatitis B, moderate chronic hepatitis B, light chronic hepatitis B in sequence. Conclusions: CD Serum sICAM-1 and sVCAM-1 levels in patients with viral hepatitis B may reflect the damage of liver. (2) Examination of serum sICAM-1 and sVCAM-1 levels in patients with hepatitis B can be used to judge the patient's condition and to diagnose. ? As an important indication of the inflammatory in Type I hypersensitivity reaction, sICAM-1 and sVCAM-1 may interfere the appearence of hepatitis B and the procedure of immunological damage of liver cells. ? Based on the result of our previous research, this work provided further provement for the probability of the interference of IgE and IgE-induced TypeI hypersensitivity reaction with the mechanism of hepatitis B.