Relationship Between The High Sensitivity C-reactive Protein And The Infection Of The Helicobacter Pylori Of The Coronary Heart Disease

Objective: To evaluate the changes of inflammation markers high sensitivity C-reactiveprotein (hs-CRP) in serum in each stage of coronary heart disease (CHD), and theassociation in the infection of Helicobacter pylori (HP) and CHD. To explore theirrelationship among inflammation, infection and CHD. This may contribute to prevent,diagnosis, treat and prognosis coronary heart disease in clinic.Methods: 60 patients with CHD were randomly recruited, including acute myocardialinfarction(AMI), old myocardial infarction (OMI), stable angina (SAP), unstable angina(UAP), and 20 healthy persons recruited as control group, their concentration of serumhs-CRP and the Hp-IgG were detected by ELISA.Results: There were significant differences between the levels of serum hs-CRP inpatients with CHD and control group (t=10.89, P＜0.01). Serum hs-CRP in each groupwith CHD (AMI, OMI, SAP, UAP) were significantly elevated compared with controlgroup. In AMI, the levels of hs-CRP was significantly higher than in UAP,OMI and SAP(F=20.71, q=4.77～9.90, P＜0.01); The levels of CRP in UAP were higher than inSAP and OMI (F=20.71, q=4.30, 5.13, P＜0.01). the Hp-lgG positive rate ofhelicobacter pylori infection in patients with CHD were higher than that of control group(x~2=4.310, P＜0.05).Conclusion: Inflammation participates in occurance and devepment of CHD, The levelsof hs-CRP may reflect the severity of CHD at some degree, and the level of hs-CRP canbe regarded as a prediction of the coronary heart disease. There is higher positive rate ofHP-IgG in patients with CHD than in control group, suggesting the HP infection may beassociated with CHD.