The Retrospective Research In Correlation Between Renal Pathology And Chinese Medicine Syndrome

Objective:Studying the correlation between renal pathology and Chinese Medicine Syndrome, so that to provide objective clinical evidence for the "syndrome" of TCM.Methods:General status, clinical information, pathological parameters, diagnoses and clinical manifestation of Xu and Shi were observed in 193 cases of kidney diseases.Results:1. Among the 193 cases, 54.90% with deficiency of qi of spleen-kidney syndrome(type 1), 20.73% with deficiency of both qi and yin syndrome(type 4) and 7.25% with deficiency of yang of spleen-kidney syndrome(type 3).2. In patients with primary glomerulus diseases, 59.7% with deficiency of qi of spleen-kidney syndrome, 16.7% with deficiency of both qi and yin syndrome, 6.9% with deficiency of yang of spleen-kidney syndrome and 5.6 % with defficiency of yin of liver-kidney syndrome(type 2). The average course of disease in the 4 types is significantly different (P＜0. 05): patients in type 3 had the longest course with 60.90±75.35 months, while type 4, type 1, type 2 had shorter course. Patients of non-deficiency type had the shortest course(mon, 0.91±0.95). While the proportions of patients with infusion of damp-heat syndrome, infusion of cold-damp syndrome, infection of wind-heat syndrome and stagnation of blood syndrome is 55.6%, 13.9%, 11.1%, 9.7%.3. In patients with secondary glomerulus diseases, 40.8% with deficiency of qi of spleen-kidney syndrome, 32.7% with deficiency of both qi and yin syndrome, 8.2% with deficiency of yang of spleen-kidney syndrome and 6.1 % with defficiency of yin of liver-kidney syndrome. Of the patients with lupus nephritis, the proportion of type 4 is largest(38.9%), while type 1 is 36.1 %, type 3, type 2 and patients with excessive heat and toxin syndrome are the same as 8.3%.4. The TCM Syndrome types of patients with primary glomerulus diseases are significantly correlated with the severity of their renal pathological changes: Semi-quantitative scoring upon pathological changes showed that the total, sclerosis and activity scores were significantly higher in patients of type 3 than in those of type 1; The total, soakage, hyperplasia and activity scores were higher in patients of type 4 than in type 1; The soakage, hyperplasia and activity scores were higher in patients with infusion of damp-heat syndrome than with infusion of cold-damp syndrome, while the hyperplasia and activity scores were higher in patients with stagnation of blood syndrome than with infusion of cold-damp syndrome.Conclusion: retrospective research proved that the TCM Syndrome type of patients with renal disease is significantly correlated with the severity of their renal pathological changes, thus, the TCM Syndrom shows definite referential importance to conclude the severity of renal pathological change in patients with renal disease.