| Purpose:To observe the characteristics of type-2-diabetic patients combine with subclinical hypothyroidism(SCH), to analyse the maybe influence of SCH to type-2-diabetic patients, and to discuss the differentiation of type-2-diabetic SCH patients with distinct syndromes of Traditional Chinese Medicine in TCM theory for ease of their treatments. Material and method:Review and select 840 type-2-diabetic patients who had taken treatments in endocrinology department of LiaoNing University hospital of Traditional Chinese Medicine during Jan 1st to Oct 31 st in 2014. Firstly, assign the ones who combine with SCH as group A(whose TSH≥10mIU/L as group A1 and the other SCH patients as group A2) while the others as group B and compare the differentiation of age, diabetic course, sex ratio, function of thyroid gland, TgAb, TpoAb, dyslipidemia and the proportion of complications associated with type 2 diabetes mellitus between the two while analyse the constituent ratio and distribution character of the syndrome of TCM in group A. Then divide all SCH patients into the corresponding groups base on the distinct syndromes of TCM and view the differentiation of clinical characteristics of them.Results: 1. Compared with the ordinary type-2-diabetic patients, the ones who combined with SCH showed characteristics as follows: more women, lower serum FT4, higher serum TSH, TgAb, TpoAb, CHOL, LDL-C and higher risks to combine with CVD, AS, DR, DKD, DPN. 2. Compared with the ordinary SCH patients, the ones whose serum TSH value no less than 10 mIU/L showed characteristics as follows: older in age, longer in type-2-diabetic course, lower in thyroid function with higher serum TgAb & TpoAb value, and greater in ratio of diabetic complications. 3. Among all 116 SCH combined type-2-diabetic patients, the most common syndrome of TCM is syndrome of deficiency of yin and yang, then syndrome of blood stasis accompanied deficiency of qi and yin, then syndrome of deficiency of qi and yin, and then syndrome of blood stasis accompanied deficiency of yin and yang. 4. Among the three syndromes of TCM in these SCH patients, the ones with syndrome of deficiency of qi and yin were younger in age, shorter in type-2-diabetic course and less in proportion of diabetic complications while higher in TG, the age and type-2-diabetic course in syndrome of deficiency of yin and yang were medium and the complication ratio of AS, DR, DKD and DPN began to rise, the ones with accompanied syndrome of blood stasis were older in age and longer in type-2-diabetic course and the highest ratio of diabetes associated complications. Conclusion: 1. Female and/or high-level-thyroid-antibody diabetic patients are more likely to combine SCH. 2. Type-2-diabetic patients with SCH are risky to combine dyslipidemia and diabetes associated complications, the higher TSH, the more risky. 3. As time passes by, the syndrome of TCM in type-2-diabetic patients with SCH are likely to transfer from syndrome of deficiency of qi and yin to syndrome of deficiency of yin and yang or to combine with syndrome of blood stasis, at last the syndrome of TCM is likely to be blood stasis accompanied deficiency of yin and yang. |
