The Influence Of Alcohol Consumption On Effectiveness Of Antihypertension In Male Patients With Essential Hypertension

Hypertension (HTN) is a clinical syndrome, which express as the blood pressure of arterial of system circulation being enhanced, it is the most common cardiovascular disease; in most patients, the reason of hypertension is not known, then it is called primary hypertension. HTN can not only cause the symptom of its own, but also be the dangerous factor of many kinds of cardiovascular disease, and effect the function of the important organism such as heart brain and kidney, make these organisms function exhausted at last.With the development of the people's life level and the enhancement of the people's lifetime, the prevalence rate of the primary hypertension is growing quickly. The high disable rate and the high death rate of HTN are paid more and more attention. Medicine is the main way to cure hypertension, while it is affected by many factors, such as drinking, smoking, psychology and so on.There are many researches on the relationship of drinking and HTN, among these it is well known that too much drinking will enhance the hypertension. Does a little alcohol consumption have the same effect, nowadays there was only a little research on this. In order to investigate the influence of alcohol consumption on effectiveness of antihypertensive in male patients with essential hypertension, especially the influence of a little alcohol consumption on effectiveness of antihypertensive in male patients with essential hypertension, we carry out this study in a village of Runan county in 2006.OBJECTIVETo investigate the influence of alcohol consumption on effectiveness of antihypertension in male patients with essential hypertension.METHODSSelect the 525 male HTN patients whose systolic blood pressure (SBP) was more than 140mmHg or diastolic blood pressure (DBP) was more than 90mmHg, age was among 32 to 65, did not take decompression medicine in a month, and exclude the syndrome of heart brain lung and kidney, according the alcohol consumption amount divide into 3 group, after 15 days angiotensin converting enzyme inhibitors (ACEI) captopril therapy, observe the curative effect one by one and then analysis. Statistic methods such as ANOVA, chi-square test were employed to analyze the data. P value less than 0.05 was considered statistically significant.RESULTS1. The common condition of the alcohol consumed team and the contrast team, the proportionality test: In different groups, the difference of height weight is not significant (P>0.05) ; The difference of age is not significant (P>0.05); the difference of smoking is not significant (P>0.05); the difference of job is not significant (P>0.05); the difference of education is not significant (P>0.05); the difference of the basic SBP and the basic DBP are not significant (P>0.05). The proportionality of different groups is good.2. Analyze on the effect of antihypertensive: after 15 days captopril therapy, the effectiveness rate of SBP is 46.5%, of DBP is 52.3%. Before the therapy, the average SBP is 146.7±5.2mmHg, after the therapy, the average SBP is 135.7±4.7mmHg, the difference is significant (P<0.05). Before the therapy, the average DBP is 93.7±3.7mmHg, after the therapy, the average DBP is 87.3±3.5mmHg, the difference is significant (P<0.05).3. The influence between the alcohol consumption and the blood pressure descendent range in antihypertensive patients: the effect of alcohol consumption on the blood pressure descendent range in antihypertensive patients is changed when the amount of alcohol consumption is changed. When the amount of alcohol consumption is zero, the blood pressure descendent range remains at a high level; when the amount of alcohol consumption is less than 30g, the blood pressure descendent range still remains at a high level; when the amount of alcohol consumption is more than 30g, the blood pressure descendent range begin to decline, and the more alcohol consumption is, the less blood pressure descendent range is. Both SBP and DBP have this character. The ANOVA was employed to analyze the blood pressure descendent range in different groups, in SBP, the difference between group 1 and the contrast group is not significant (P>0.05), the difference between group 2 and the contrast group is significant (P<0.05); in DBP, the difference between group 1 and the contrast group is not significant (P>0.05), the difference between group 2 and the contrast group is significant (P<0.05).4. The influence of alcohol consumption on effectiveness of antihypertensive in patients: after 15 days captopril therapy, the effectiveness of antihypertensive in SBP in contrast group, group 1. group 2 is: 55.3%. 47.1%. 37.3%; in DBP in contrast group, group 1. group 2 is: 56.2%. 47.8%. 52.8%. The chi-square test was employed to analyze the effectiveness of antihypertensive in different groups, in SBP, the difference between group 1 and contrast group is not significant (P>0.05), the difference between group 2 and contrast group is significant (P<0.05); in DBP, the difference between group 1 and contrast group is not significant (P>0.05), the difference between group 2 and contrast group is not significant (P>0.05).5. The comparison between the accomplished group and the missing group: between the accomplished group and the missing group, the difference of height weight is not significant (P>0.05); the difference of age is significant (P<0.05); the difference of smoking is not significant (P>0.05); the difference of job is not significant (P>0.05); the difference of education is significant (P<0.05); the difference of basic SBP is significant (P<0.05); the difference of basic DBP is not significant (P>0.05).CONCLUSIONS1. If alcohol consumption is less than 30g per day, it will not influence the effectiveness of antihypertensive in male patients both in SBP and in DBP.2. If alcohol consumption is more than 30g per day, it will decline the effectiveness of antihypertensive in male patients in SBP, while it will not influence that in male patients in DBP.3. If alcohol consumption is less than 30g per day, it will not influence the blood pressure descendent range in male patients after the antihypertensive therapy both in SBP and in DBP.4. If alcohol consumption is more than 30g per day, it will decline the blood pressure descendent range in male patients after the antihypertensive therapy both in SPB and in DBP, the more alcohol consumption is, the less blood pressure descendent range is.