Effects Of Alcohol Consumption On The Severity Of OSA And Serum SP Protein Concentration In Male Hypertensive Population

Objective:To investigate the effect of alcohol consumption on the severity of obstructive sleep apnea syndrome（OSA）and serum alveolar surfactant protein（SPs）concentration in male hypertensive patients,and analyze the relationship between alcohol consumption and the severity of OSA.Methods:90 male hypertensive patients with a history of drinking over the age of 18 were included,and polysomnography（PSG）was performed overnight before and after alcohol consumption,and at different times before and after alcohol consumption blood samples were collected in sections to determine the concentrations of serum SP-A,SP-B,SP-C and SP-D,and to compare the apnea hypopnea index（AHI）,the lowest saturation of oxygen（LSaO₂）and serum SPs concentration before and after alcohol consumption,analysis of the relationship between serum SPs and AHI and LSaO₂.Results:AHI increased significantly after alcohol consumption compared with the situation before alcohol consumption（25 vs 30.2 events/h,P=0.001）,LSaO₂ decreased significantly（79 vs 75%,P<0.001）;serum SP-B concentration before alcohol consumption was 8.2ng/ml,7.3ng/ml 2h after ingestion,and 8.5ng/ml the next morning,there was a significant difference among the three groups（P=0.002）;SP-D concentrations were 3.9ng/ml,3.4ng/ml,4.2ng/ml,there were also significant differences among the three groups（P=0.026）.In the analysis grouped by AHI and BMI,in the AHI<30 events/h group,there was a difference of AHI which was 7.3 events/h and 16.3 events/h before and after alcohol consumption,respectively,（P<0.001）,serum SP-B concentration at different drinking time periods were 8.1ng/ml,7.5ng/ml,and 9ng/ml,the alteration were more obvious（P=0.019）,and there was a statistical difference of serum SP-D concentration between the periods after alcohol consumption 2h was 2.7ng/ml and the next morning was3.6ng/ml（P=0.02）;in the group of BMI≥28 Kg/m²,LSaO₂ was 71%after alcohol consumption was significantly lower than 76%which before consumption（P=0.001）,The serum SP-B concentrations were 7.45ng/ml,6.47ng/ml and 8.15ng/ml,respectively,and significantly changed（P=0.002）.There was no significant difference in serum SP-D concentration at different drinking time periods.Further multiple linear regression analysis confirmed that the change of serum SP-B concentration was significantly correlated with AHI（R²=0.213,P=0.04）.Conclusion:In the male hypertensive population,the severity of OSA increased significantly after alcohol consumption and the concentration of serum SP-B and SP-D decreased,and there was a significant correlation between SP-B and AHI;suggesting OSA severity after alcohol consumption increased is related to changes in serum SP-B and D concentrations.