B-type Natriuretic Peptide (BNP) And Risk Factors Of Coronary Heart Disease

BACKGROUNDNow cardiovascular disease is still an important problem, which affects the health of human being. With the improvement of material life, people pay more attention to the healthy problems, so if suffering from disease they want to be early diagnosed, early prevented, and early treated. A kind of marker is needed to predict the pathological changes of heart function and heart failure. B-type natriuretic peptide (BNP) has being used in the diagnosis and prognosis of heart failure and also in the curative effect monitor, but the studies on the relationship between BNP and risk factors of coronary heart disease are few. In this study, we investigated the relationship between BNP and risk factors of coronary heart disease to find out the value of BNP.Methods The data, including body weight index(BMI), smoking history, blood pressure, blood glucose, blood lipids, CRP, and echocardiography (ECG), were collected from the people who came toour hospital for physical examination from the year July 2005 to June 2006. BNP levels were compared between the people with different age, gender, smoking history, blood pressure, blood glucose, blood lipids, and CRP.Results Hypothesis test showed that BNP level was higher in the people ≥ 50 years old than in the people < 50 years old, and was higher in the female than in the male. People with hypertension history, or the second phase of hypertension, or with diabetes had higher BNP level than normal people did. BNP level was lower in the people with increased lipids than that in the normal people; there was no significant difference between people with different BMI and smoking history, or with cholesterin, or abnormal low density lipoprotein, or abnormal high density lipoprotein and normal people. There has a positive correlation between CRP and BNP. Linear-regression analysis showed: gender, and blood pressure had statistical significance. The linear equation was F=429.50, P<0.0001.Conclusion BNP was positively correlated with female, age, blood pressure, blood glucose, while BNP was negatively correlated with blood lipids. There was no correlation between BNP and BMI, smoking histroy, cholesterin.