Clinical Analysis Of 5 Cases Of HELLP Syndrome With Severe Pre-eclampsia

Objective: To summarize the pathogeny, diagnosis, treatment and prognosis of patients with hemolysis,elevafed liver enzymes, and low platelet count (HELLP) syndrome.Methods: The clinical data (age, gestation, clinical expression, diagnosis, treatment and prognosis) of the five cases of HELLP syndrome with severe pre-eclampsia were analyzed retrospectively.Results: The incidence of HELLP syndrome was 2.62% in the patients with severe pre-eclampsia, age of the patients was ranging between 22-35 years old, gestational age of the patients was ranging between 33-36 weeks, four of five were primigravida, one of five was multigravida,and one patient had the medical record of severe pre-eclampsia. The blood pressure was ranging between 139-221/89 - 133mmHg, the urine protein was (+ +) — (+ + +) .Two patients had the symptoms of nausea,vomit and ache in the midsection; three patients had the symptoms of headache, swirl and giddiness; one patient hadmelena; one patient had hematuria; all the patients had ascites and/or thorax hydrocele; two of five had skin petechia; two patients had gum hemorrhage. All the patients had hypochromia (66 - 105g/l), ALT and AST elevated to (56-534U/L) and (98-352U/L), LDH elevated to (117 -1044U/L),blood platelet descended to (21-52×10^9/L),TG elevated to (1.85-3.08mmol/l), HDL descended to (0.56-1.08 mmol/l) .with LDL/HDL rising. One patient had the sequel of placental abruption,and three patients had the sequel of FGR, and one with fetal distress.The major trerapeutic ways were intensive maternal and fetal monitoring, active treatment of pre-eclampsia, use of corticosteroids and termination the pregnancy as fast as possible. The five patients all recovered, the newborn babys were alive in four cases, one fetal died in uterus.Conclusion: HELLP syndrome is a serious life-threatening compliacation with severe pre-eclampsia, obstetrician must improve the recognition of the incidence and fatalness of HELLP syndrome, master the characteristic of clinical expression and laboratory examination, we must manage pre-eclampsia and administrate corticosteroids forepart and terminate the pregnancy as fast as possible if the diagnosis is clear.