| Objective: Functional dyspepsia (FD) is a common gastrointestinal functional disease in clinical.Symptoms of FD are characterized by upper abdominal pain or discomfort,early satiety,postprandial fullness, bloating, nausea and vomiting.The pathogenesis of FD is not clearly defined and it is involves psychology factors,wrong diet,gastrointestinal internal secretion abnormalities,gastrointestinal motor abnormalities and helicobacter pylori-positive.Recently,the research with FD has great development with using new technology.Gastrointestinal motor abnormalities and gastroin- testinal internal secretion abnormalities have all been considered as major pathogenic factors. Gastrointestinal internal secretion abnormalities can change the level of gastrointestinal hormone and gastrointestinal hormone is the major adjustable factor of gastrointestinal motor. Gastrointestinal hormone is involved motilin (MTL),vasoactive intestinal peptide (VIP),somatostatin (SS),cholecystokinin (CCK) and substance P (SP).The levels of gastrointestinal hormone in plasma are often been researched.The purpose of this study is to evaluate the mucosal levels of CCK and SP with FD and to explore their roles and clinical significance in the pathogenesis of FD.Methods:The standard of criteria is Romeâ…¡criteria.The mucosal levels of CCK and SP were measured by Radio Immunoassay (RIA) in 41 patiens with FD,and compared with 14 normal non-atopic controls.Results:Patients with FD had significant increase in mucosal levels of CCK compared with controls (P<0.01).And the mucosal levels of SP were higher in the patients with FD than in the controls (P<0.01).Conclusions: Patients with FD had significant increase in mucosal levels of CCK and SP compared with controls, which supports that CCK and SP play a role in the pathogenesis of FD and gastrointestinal internal secretion abnormalities is related with FD. Development of antagonist and inhibitor of neuropeptides may offer a new approach to the treatment of patients with FD.
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