Relationship Between Abnormal Pregnancy Outcomes And TORCH Infections In Pregnant Women

TORCH infections include infections associated with toxoplasma (TOX), rubella virus (RUV), cytomegalovirus (CMV), herpes simplex virus,(HSV) and other organisms. Most maternal TORCH infections have few symptoms, but may cause fetal and neonatal congenital infections, which will lead to abortion, fetal death, stillbirth, congenital deformity, neonatal death, low birth weight and symptoms of central nervous system (chorioretinitis, deafness, mental deficiencies) later in life.In recent years, the perinatal TORCH infections are increasingly attracted widespread attention from many internal obstetricians at home and abroad, with a great deal of investigations being carried on. But now, there is a great variance between these reported incidences of TORCH infection in the mother and the diagnosis and the management of these patients is still a tough problem. Objective: To investigate the relationship between abnormal pregnancy and TORCH infections in pregnant women, and provide a guidance to the diagnostic tests of choice for the diagnosis and management of these women.Methods: Enzyme linked immunosorbent assay (ELISA) are used to detect TORCH IgG and IgM in blood serum of pregnant women with abnormal pregnancies(Study Group, n = 132, including 90 women with early pregnancy and 42 women with midtrimester or late pregnancy), and normal pregnant women (Control Group, n = 138, including 90 women with early pregnancy and 48 women with midtrimester or late pregnancy). Results:â‘ In Study Group, the total positive rates of TORCH-IgG: TOX-IgG 14.39%, RUV-IgG 20.45%, CMV-IgG 65.15%, HSV-2-IgG 27.27%.And these rates in Early Pregnancy Group are 13.33%, 20.0%, 65.56%, 22.22%; in Midtrimester or Late Pregnancy Group are 16.67%, 21.42%, 64.29%, 38.10%; and in Control Group,the total positive rates of TORCH-IgG: TOX-IgG 4.35%, RUV-IgG 7.25%, CMV-IgG 18.84%, HSV-2-IgG 7.25%. And these rates in Early Pregnancy Group are 4.44%, 7.78%, 20.0%, 5.56%; in Midtrimester or Late Pregnancy Group are 4.17%, 6.25%, 16.67%, 10.42%. The positive rates of TORCH- IgG of Early Pregnancy Group and Mid- trimester or Late Pregnancy Study Group are significantly higher than those of Control Group respectively (P < 0.05). But, in Study Group, the differences of positive rates between Early Pregnancy Group and Mid- trimester or Late Pregnancy Group is not significantly (P> 0.05).Either in Study Group or in Control Group, the positive rates of CMV- IgG is highest.â‘¡In Study Group, the total positive rates of TORCH-IgM: TOX-IgM 18.94%, RUV-IgM 12.12%, CMV-IgM 15.15%, HSV-2-IgM 12.88%. And these rates in Early Pregnancy Group are 20.0%, 12.22%, 15.56%, 16.81%; in Midtrimester or Late Pregnancy Group are 16.67%, 11.90%, 14.29%, 9.52%; and in Control Group,the total positive rates of TORCH-IgM: TOX-IgM 4.34%, RUV-IgM 2.17%, CMV-IgM 2.90%, HSV-2-IgM 0.72%. And these rates in Early Pregnancy Group are 4.44%, 2.22%, 3.33%, 1.11%; in Midtrimester or Late Pregnancy Group are 4.17%, 2.08%, 2.08%, 0%. The positive rates of TORCH- IgM of Early Pregnancy Group and Mid- trimester or Late Pregnancy Study Group were significantly higher than those of Control Group respectively (P < 0.05). But, in Study Group, the differences of positive rates between Early Pregnancy Group and Mid- trimester or Late Pregnancy Group is not significantly (P> 0.05). Conclusion:â‘ TORCH active infection is one of the important causes of abnormal pregnant outcomes.â‘¡CMV infection of women during child-bearing period is the most widespread .â‘¢It is necessary both to screen TORCH infection for women who have the histories of abnormal pregnancies or have got in touch with infection sources closely, and to diagnose and treat those active infectious pregnant women promptly.