Clinic Alanalysis Of Infantile Hepatitis Syndrome

Objective : To analyze the etiology .clinical features and therapy efficacy of infantile hepatitis syndrome .Methods : Retrospective analysis of the database was performed on patients present with the onset of infant . jaundice , hepatomegaly and liver function abnormalities . Detect TORCH-IgM and TORCH-IgG by the way of enzyme-linked immunosorbent assay , also adopt imageology and metabolic disease screening methods . 21 cases infected by TORCH were treated with Ganciclovir .Results :1. Of the 44 patients with infantile hepatitis syndrome , 24 of which were identified to be infected by pathogenic micro-organism , the infective rate was 54.5%; 21 cases were infected by TORCH (47.7%) . 11 only by CMV , and 8 by CMV compared with other viruses ;1 only by HSV ; 7 cases were caused by HBV infection , 4 of which were complicated with TORCH infection ; and 5 cases suffered from congenital liver and gall dysplasia , among which 2 cases were identified to be congenital cholangioclse and accepted operation named Kasai. 12 cases are still etiology-unknown(27.3%).2. Ail cases came for persisitent jaudance or delayed regression , and 43 combined with respiratory infection(97.7%) ;26 with alimentary system infection (59.1%) ; 5 with intracranial hemorrhage , 5 with cardiovascular system malformation , 5 with umbilical hernia , each takes 11.4% . Physical examination indicated that 42 occurred hepatomegaly (95.4%). 44 cases suffered Hepatic function damage . 3. 44 cases were offered ordinary therapy , 14 days were set as a course of treatment,indexes for evaluating curative effects such as ALT , TBIL , DBIL and liver size degraded markedly (p<0.001) . Effective power came to 86.4% after 1 to 3 courses of treatment.4. 6 cases were curinged , percentage was 13.6% ; 15 excellence , took 34.1% ; 17 utility ones , percentage was 38.6% ; and 6 were invalid ones (including 3 cases voluntarily discharge ), took 13.6% .Conclusion :1. Infection is still the chief cause of infant hepatitis syndrome, in which TORCH infection takes the main parts , infection rate is 47.7% ; and HBV infection can not be ignored , most cases are infected by the way of vertical transmission , infection rate is 15.9% .2. Most cases came for persisitent jaudance or delayed regression , Physical examination indicated that 42 occurred hepatomegaly (95.4%) . 44 cases suffered Hepatic function damage .and bilirubin lever increases , ratio of direct bilirubin in total fluctuates 40% to 50% .3. IFH usually combines with multisystem damages , such as malformation , secondary infections , intracranial hemorrhage , thyroid hypofunction and skin rash , et al. The respiratoy infection rate is 97.7% .4. Supplying ordinary therapy , curing cases infected by viruses with Ganciclouir and operating on infants with biliary atresia or choledochal cyst.5. Effective power came to 86.4% after 1 to 3 courses of treatment.