Patients With Acute Coronary Syndrome.NF-κB CPR Activity And Clinical Intervention Study

Background: According to WHO statistics, coronary heart disease is the most common cause of death in the world, also known as "the first killer." Acute coronary syndrome and acute coronary syndrome ACS) is an important part of acute coronary heart disease events, which occurred in unstable plaque cracks. Decomposed formed on the basis of thrombosis or rupture, resulting in acute myocardial ischemia. In recent years, awareness of the incidence of inflammation in unstable plaques, and the evolution plays a vital role in the process of plaque rupture.C-reactive protein (C-reactive protein CRP) in response to various acute vascular inflammation, and plasma protein markers in the study, CRP was considered the most acute cardiovascular events in the inflammatory markers of inflammation in acute phase, in the role of various inflammation, increased plasma levels of IL-6. Liver cells reactive produce CRP, endothelial tissue can also pose a small amount of C-reactive protein, CRP merely as a marker of vascular inflammation or have other specific functions, it is not clear that CRP is a nonspecific marker of inflammation, inflammation, infection and tissue damage at higher concentrations it can depend on the degree of inflammation. The current study that vascular (endothelial dysfunction oxidative stress, etc.) and vascular (the infection) factors leading to the inflammatory reaction, inflammatory response caused the production of cytokines, further induction of acute phase reactants (CRP) of these substances into the arterial circulation in the development of atherosclerosis. Access levels are all indicators of the risk associated with coronary thought, but they have different types of coronary heart disease, especially in patients with ACR their risk stratification and prediction, there is rarely reported. NF-κB is the main mechanism to control inflammation, NF-κB cells regulate gene transcription is one of the key genes, which may be activated in the process of plaque rupture started, activation of NF-κB to a variety of factors, including 1B, IL-6, IL-17, TNF-α. Oxygen free benzene oxidation of LDL. mechanical stress, activation of NF-κB entered the nucleus, and its target genes, and thereby to induce many factors in patients with ACS,NF- kB an increasing trend But this white blood cell activation of NF-κB cells are derived from the contact patch or patches to the release of certain elements in the role of NF-KB WBC is not yet clear, inflammatory cells before the transcription factor NF-KB excitement factor in the development of CHD play a role. But NF-KB activity in the types of patients with ACS (UAP were more likely to be elder ELEVATION) and CRP and the differences between the experimental results to be further confirmed.In recent years, the angiotensin II (angiotensin II) role in the pathogenesis of atherosclerosis and in the pathogenesis of new ideas, and more research shows that angiotensin converting enzyme inhibitors (AIEI) and angiotensin II receptor (AT1) antagonist will not only reduce the volume of plaque, but also reduced macrophage accumulation. lower cholesterol levels and increased extracellular matrix, reduce inflammatory markers in patients with ACS, thereby reducing vascular sensitivity to oxidative stress, played a stabilizing role in the patch. How to identify unstable plaques, ACS predict the risk is that people are facing new challenges, stable plaques to prevent plaque rupture is a new direction for the future treatment of ACS. Therefore choice of external blood reflect plaques characteristic indicators of the inflammatory process in a comprehensive evaluation to identify unstable plaques identifying forecast plaque rupture serum markers used in clinical work is very real value. Therefore the issue of patients with acute coronary syndrome KB, LRP activity and intervention was carried out.Objective : To investigate the activity NF-KB.HS.CRP acute coronary syndrome, in different degrees of severity of the changes, as well as pages ofNF- kB losartan treatment for patients with ACS. CRP activity and its clinical significance.Methods : The gel mobility test (EMSA) and sandwich enzyme-linked immunosorbent assay for determination of 40 subjects, 128 patients with ACS. Including unstable angina pectoris (UAP)56 case, 34 cases of non-ST-segment elevation myocardial infarction (NSTEMI) 34, ST-segment elevation myocardial infarction (STEMI) 36patients and gray NF- κ B HS-.CRP integral concentration, and 128 patients were selected randomly according to the principle of the treatment group were 72cases, control group of 56 patients for 30 days granted pages losartan 80g/d its NF- kB. HS-.CRP for complex measurement.Results : ACS NF_KB. HS-CRP 0.05 per capita level significantly higher than normal, (p<0.05)NF-KB.HS-CRP level from UAP, NSTEM2. STEM2 group gradually increased,NF- kB integral Gray were (26.07 ± 12.98 , 31.01 ± 13.21, 37.06±13.98). HS-CRP concentration (9.53 ±0.76, 10.24±1.17, 15.12±0.68,)(,p<0.05.) There were significant differences among the groups, the use of the resultant page losartan treatment group compared with control group, 30 days after its KB, HS-CRP has shown a declining trend in the control group did not meet the requirements, the treatment group was significantly decreased (P <0.05).Conclusion : ACS patients have early inflammatory cells before the excitement factor activation of the transcription factor NF-κB and inflammatory reactive protein (CRP), and NF-KB, HS-CRP there are differences in the severity of ACS, who significance to the extent forecast,NF- kB integral unity page irbesartan can reduce the level of intensity and concentration HS-CRP, inhibiting the inflammatory reaction.