The Clinic Relevance Between Plasma High Sensitivity C-reactive Protein,von Willebrand Factor,von Willeband Factor-cleaving Protease Levels And Acute Coronary Syndrome

Objective To evaluate the role of plasma high sensitivity C-reactive protein, von Willeband factor, von Willebrand factor-cleaving protease in the pathogenesis of acute coronary syndrome.Methods 68 subjects were divided into four groups. ACS included UA and AMI. 17 patients presenting with UA(10 men and 7 women, mean age 57.8 ± 10.1 years), 17 patients presenting with AMI(11 men and 6 women, mean age 57.2 ± 9.8 years),The ACS patients had plasma samples taken on admission and when recovered. 17 patients presenting with SA(9 men and 8 women, mean age 58.1±9.6 years), 17 healthy controls group(10 men and 7 women, mean age56.2±9.8 years) as comparison. Plasma levels of von Willebrand factor (vWF) and high sensitivity C-reactive protein (hs-CRP) were measured using enzyme like immunosorbent assay (ELISA). The plasma von Willebrand factor-cleaving protease (vWF-cp) activity was measured by residual collagen binding activity (R-CBA). Coronary angiography was performed in all patients and normal control persons.Results ①Plasma levels of hs-CRP, vWF were significantly higher inpatients with ACS than those with SA(p < 0.01) and normal controls (p < 0.01) ;but no difference between the latter two groups(p > 0.05).②The plasma vWF-cp activity was significantly lower in patients with ACS than those with SA (p<0.01) and normal controls(p < 0.01); but no difference between the latter two groups(p > 0.05).③In all of the patients ,the alteration of hs-CRP and vWF were more sensitive, while that of v WF-cp was more specific. Measurement of the plasma vWF -cp and hs-CRP levels were more sensitive and specific. In ACS patients the...