| Objective: To determine whether cord blood IgE predicts the development of asthma and other IgE-mediated allergic diseases in infants at 3 months,6 months or one year.Methods: Total cord blood IgE level of 134 infants were measured using Flouoroenzymeimmunoassay UNICAP100Ra (Pharmacia&Upjehn). 134(100%)of the infants were followed up by telephone or were asked to come to clinic.The atopic diseases such as dermatitis,recurrent analyzed statiscally to use EXCEL for Windows.Result: In 134 samples, cord blood IgE above 100KU/L was excluded from the analysis because of possible contamination with maternal blood. The average IgE was up to 32.5KU/L,which is too much high.68.7%(92/134) infants had detectable total IgE in cord blood above 0.35KU/L 100%(134/134) of the 134 infants followed up had the detectable IgE68.7 %(84/134) of the 134 infants had the allergic diseases, 47.0%(63/134) had the dermatitis,18.7%(25/134) had the urticaia and 9.0%(12/134) had the recurrent wheezing.The corresponding figures of the infants with cord blood IgE below 0.35KU/L were 6.0% (8/134),2.2%(3/134),3.0%(4/134) and 3.0%(4/134),respectively. There was significant difference between two groups in the development of the allergic diseases, of the dermatitis and of the urticaria.Conclusion: The atopic disease especially the dermatitis and urticaria of theinfants was significantly more frequent among infants with the cord IgE above 0.35KU/L.The elevated cord blood IgE was found a significant predictor for the development of the atopic disease especially the dermatitisand urticaria of the infants.The allergic family history was higher when the cord blood IgE above 0.35KU/L combined with the family history.
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