| Objective: The plasma concentration of C reaction protein (CRP) and homocysteine (HCY) were analyzed to explore the relationship of CRP and HCY with risk of essential hypertension (EH) and hypertension with left ventricular hypertrophy.Method: Thirty hypertension patients (16 males and 14 females, age from 56 to 69 years, 62±6.5) were recruited in hypertension group. Thirty four subjects who have normal blood pressure were enrolled in the control group, aged from 51 to 72 years (58±5.4). Ultrosonic cardiography was used to measure the interventricular septal thickness (IVST), left ventricular internal diameter (LVID) as well as left ventricular posterior wall thickness (LVPW) in the end of diastolic dimension, according to these parameters as well as patients'heights and weights, left ventricular mass index (LVMI) was calculated, and based on LVMI (LVMI male≥125g/m2, female≥110g/m2), 30 patients were divided into two groups: group A (without left ventricular hypertrophy), 19 patients(10 males, 9 females) and group B (with left ventricular hypertrophy), 11 patients(6 males, 5 females). Concentration of blood sugar, lipid, CRP and HCY were measured to analyze the correlation of plasma CRP and HCY with risk to essential hypertension and hypertension with left ventricular hypertrophy.Results: Plasma concentrations of CRP and HCY in EH were significantly higher than those in control group (p<0.01). Among EH group, CRP level in group B was clearly higher than that in group A, while the HCY level was on the contrary (p<0.05). It was shown by multiple unconditional logistic regression analysis that high plasma concentration of CRP increased the risk of hypertension with left ventricular hypertrophy(P=0.006,OR=2.19). Correlation analysis indicated that CRP and HCY level was positively correlated with MBP in population, that is, individuals with higher plasma CRP and HCY concentration had higher blood pressure.Conclusions: High CRP and HCY concentrations suggest that essential hypertension is associated with vessel endothelial dysfunction. The remodeling of left ventricular caused by EH is correlated with CRP plasma concentration and has no obvious correlation with HCY level. CRP and HCY level is positively correlated with blood pressure. |
