Application Research Of BIS Monitoring System For Sedation Of Patients Mechanically Ventilated In ICU

Sedation is an important aspect of sedation in mechanically ventilated ICU patients. Anxiety and agitation often occurs in these patients which can cause noxious affects. Therefore, the use of sedatives to maintain patient safety and comfort is often essential to these patients. However, over-sedation or under-sedation may increase the incidence of the complications and mortality in mechanically ventilated patients. So the optimized protocols of sedation are required to effectively select drugs and monitoring. This experiment consists of three parts to evaluate the application of BIS monitoring the sedation of ICU patients who required mechanically ventilation. Part One: Estimating application of BIS monitoring the sedation of mechanically ventilated ICU patientsObject: To evaluate application of BIS monitoring the sedation of 30 mechanically ventilated ICU patients by analyzing the correlation between BIS and Ramsay sedation scales. Methods and Outcomes: Assessing the depth of sedation with Ramsay sedation scales, the BIS medians corresponding to sedation scales score were compared respectively. And analyzing the correlation between BIS and sedation scales was obtained. We found that the medians of BIS values decreased with the increasing of the depth of sedation and the difference among the scales could be observed in patients. The r-value of BIS values and Ramsay scales were -0.794 (P< 0.001). The medians varied significantly corresponding to the subjective scale((P< 0.001). The frequency of BIS median in range of 2~5 score was 372 and a BIS value >80 had a sensitivity of 0.86 and Youden index of 0.15.Conclusions: BIS can monitor the sedation of ICU mechanically ventilated patients objectively to adapt the sedation treatment.Part Two: Comparing the utility of midazolam and propofol by BIS monitoring sedation in ventilated ICU patientsObject and Methods: By BIS monitoring sedation objectively, we compared the effect and security between midazolam and propofol in 30 ventilated ICU patients who were divided two groups. Setting the optimal end-point as BIS in range of 70~...